Roflumilast
CHEBI:CHEBI_47657
Definition
A benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary disease.
Chemical Information
- Molecular Formula
- C17H14Cl2F2N2O3
- Molecular Mass
- 403.20700
- Charge
- 0
- SMILES
- FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl
- InChI
- InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
- InChIKey
- MNDBXUUTURYVHR-UHFFFAOYSA-N
Alternative Names
- 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
- Daliresp
- roflumilast
- roflumilastum
Drug Classification
-
benzamidesView Class →
CHEBI:22702
-
cyclopropanesView Class →
CHEBI:51454
-
aromatic etherView Class →
CHEBI:35618
-
organofluorine compoundView Class →
CHEBI:37143
-
chloropyridineView Class →
CHEBI:39173
-
t227737
-
t228255
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 1091836
- oboInOwl#hasDbXref
- Wikipedia:Roflumilast
- core#notation
- CHEBI:47657
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- marketing_category
- BULK INGREDIENT
- listing_expiration_date
- 20241231
- route
- TOPICAL
- labeler_name
- Sintenovo SA de CV
- marketing_start_date
- 20221015
- application_number
- ANDA208247
- spl_id
- f086d8f9-3cf8-4196-a422-c4117bd1fcaf
- package_ndc
- 80610-115-96
- product_type
- DRUG FOR FURTHER PROCESSING
- package_description
- 6 TUBE in 1 CARTON (80610-115-96) / 5 g in 1 TUBE (80610-115-05)
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1091836
- oboInOwl#hasDbXref
- Wikipedia:Roflumilast
- oboInOwl#id
- CHEBI:47657
- brand_name
- ZORYVE
- brand_name_base
- ZORYVE
- generic_name
- ROFLUMILAST
- dosage_form
- CREAM
- product_ndc
- 80610-115
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_68844
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- owl#annotatedSource
- t228366
- owl#someValuesFrom
- t3892835
- core#notation
- CHEBI:47657
- rxcui
- 2001321
- active_ingredient_strength
- 50 kg/50kg
- manufacturer_name
- Arcutis Biotherapeutics, Inc.
- package_marketing_start_date
- 23-JAN-18
- active_ingredient_name
- ROFLUMILAST
- unii
- 0P6C6ZOP5U
- spl_set_id
- fa9c3bea-a04d-4ea9-ade9-ee8d9f6b1f72
- nui
- N0000182960
- upc
- 0303781905930
- pharm_class_epc
- Phosphodiesterase 4 Inhibitor [EPC]
- pharm_class
- Phosphodiesterase 4 Inhibitors [MoA]
- pharm_class_moa
- Phosphodiesterase 4 Inhibitors [MoA]
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class