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Ethambutol

CHEBI:CHEBI_4877

Definition

An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.

Chemical Information

Molecular Formula
C10H24N2O2
Molecular Mass
204.30980
Charge
0
SMILES
CC[C@@H](CO)NCCN[C@@H](CC)CO
InChI
InChI=1S/C10H24N2O2/c1-3-9(7-13)11-5-6-12-10(4-2)8-14/h9-14H,3-8H2,1-2H3/t9-,10-/m0/s1
InChIKey
AEUTYOVWOVBAKS-UWVGGRQHSA-N

Alternative Names

  • (+)-2,2'-(ethylenediimino)di-1-butanol
  • (+)-ethambutol
  • (+)-N,N'-bis(1-(hydroxymethyl)propyl)ethylenediamine
  • (+)-S,S-ethambutol
  • (2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol
  • (2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol
  • (S,S)-ethambutol
  • EMB
  • etambutol
  • ethambutol
  • Ethambutol
  • ethambutolum
  • S,S-Ethambutol

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Ethambutol
DRON_00010000
4110
core#notation
CHEBI:4877

Additional References

Wikipedia:Ethambutol

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Ethambutol
DRON_00010000
4110
oboInOwl#hasAlternativeId
CHEBI:678172
oboInOwl#id
CHEBI:4877
product_type
BULK INGREDIENT
dosage_form
POWDER
marketing_category
BULK INGREDIENT
labeler_name
STI Pharma LLC
generic_name
Ethambutol hydrochloride
brand_name
ETHAMBUTOL HYDROCHLORIDE
brand_name_base
ETHAMBUTOL HYDROCHLORIDE
product_ndc
70518-2966
application_number
NDA016320
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35703
oboInOwl#inSubset
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core#notation
CHEBI:4877
rxcui
995607
listing_expiration_date
20241231
route
ORAL
active_ingredient_strength
25 kg/25kg
marketing_start_date
19941031
pharm_class
Antimycobacterial [EPC]
package_marketing_start_date
10-AUG-07
manufacturer_name
STI Pharma LLC
spl_id
228ec1c0-674e-f0c9-e063-6394a90a9399
active_ingredient_name
ETHAMBUTOL HYDROCHLORIDE
package_ndc
70518-2966-0
package_description
30 TABLET in 1 BLISTER PACK (70518-2966-0)
unii
QE4VW5FO07
spl_set_id
c12b3482-55f0-4324-bdcd-b129ca2dae73
upc
0342806102015
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