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deferasirox

CHEBI:CHEBI_49005

Definition

A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.

Chemical Information

Molecular Formula
C21H15N3O4
Molecular Mass
373.36162
Charge
0
SMILES
OC(=O)c1ccc(cc1)-n1nc(nc1-c1ccccc1O)-c1ccccc1O
InChI
InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,25-26H,(H,27,28)
InChIKey
BOFQWVMAQOTZIW-UHFFFAOYSA-N

Alternative Names

  • 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
  • deferasirox
  • deferasiroxum
  • Exjade
  • ICL 670
  • ICL 670A

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
614373
oboInOwl#hasDbXref
Reaxys:8442898
core#notation
CHEBI:49005

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
614373
oboInOwl#hasDbXref
Reaxys:8442898
oboInOwl#id
CHEBI:49005
generic_name
Deferasirox oral
brand_name
Deferasirox oral
brand_name_base
Deferasirox oral
product_ndc
59651-419
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38157
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_855
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
TABLET, FOR SUSPENSION
application_number
ANDA213374
package_ndc
59651-419-37
route
ORAL
spl_id
e75fb335-3efa-44d0-a8ef-e974b3fd606b
listing_expiration_date
20241231
marketing_start_date
20170212
labeler_name
Amoli Organics (A Division of Umedica Laboratories Pvt. Ltd.)
core#notation
CHEBI:49005
active_ingredient_strength
360 mg/1
nui
N0000175522
pharm_class_moa
Iron Chelating Activity [MoA]
pharm_class
Iron Chelating Activity [MoA]
active_ingredient_name
DEFERASIROX
pharm_class_epc
Iron Chelator [EPC]
upc
0367877676722
spl_set_id
97a62d3d-b910-4d2d-abf6-19ffa33e7005
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
package_description
50 kg in 1 DRUM (59651-419-37)
rxcui
1923829
manufacturer_name
Xiromed, LLC
package_marketing_start_date
20200616
unii
V8G4MOF2V9
has_treatment
http://purl.obolibrary.org/obo/DOID_2350
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect26298
owl#annotatedSource
t231629
owl#someValuesFrom
t3161047