Discuss This Drug

Vandetanib

CHEBI:CHEBI_49960

Definition

A quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.

Chemical Information

Molecular Formula
C22H24BrFN4O2
Molecular Mass
475.35412
Charge
0
SMILES
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
InChI
InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
InChIKey
UHTHHESEBZOYNR-UHFFFAOYSA-N

Alternative Names

  • 4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE
  • N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
  • vandetanib
  • Zactima
  • ZD 6474
  • ZD6474

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Vandetanib
DRON_00010000
1098413
core#notation
CHEBI:49960

Additional References

Wikipedia:Vandetanib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Vandetanib
DRON_00010000
1098413
oboInOwl#hasAlternativeId
CHEBI:49959
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38637
oboInOwl#id
CHEBI:49960
core#notation
CHEBI:49960
generic_name
vandetanib non-mc
rxcui
1114096
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20251231
route
ORAL
active_ingredient_strength
1 kg/1
nui
N0000175076
pharm_class_moa
Protein Kinase Inhibitors [MoA]
pharm_class
Protein Kinase Inhibitors [MoA]
dosage_form
POWDER
marketing_start_date
20110406
pharm_class_epc
Kinase Inhibitor [EPC]
package_marketing_start_date
06-APR-11
labeler_name
Genzyme Corporation
active_ingredient_name
VANDETANIB
product_ndc
63069-784
spl_id
27413760-1ab4-f7af-e063-6394a90aa478
package_ndc
63069-784-03
package_description
30 TABLET, FILM COATED in 1 BOTTLE (63069-784-03)
manufacturer_name
Genzyme Corporation
brand_name
CAPRELSA
brand_name_base
CAPRELSA
application_number
NDA022405
unii
YO460OQ37K
spl_set_id
e5721cb8-4185-47b9-bbb3-1c587e558a03
oboInOwl#inSubset
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http://www.w3.org/2002/07/owl#Class
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http://purl.obolibrary.org/obo/DOID_6174
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t234836
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