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Vandetanib

CHEBI:CHEBI_49960

Definition

A quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.

Chemical Information

Molecular Formula
C22H24BrFN4O2
Molecular Mass
475.35412
Charge
0
SMILES
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
InChI
InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
InChIKey
UHTHHESEBZOYNR-UHFFFAOYSA-N

Alternative Names

  • ZD 6474
  • ZD6474
  • 4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE
  • N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
  • vandetanib
  • Zactima

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:49960
oboInOwl#hasDbXref
Wikipedia:Vandetanib
DRON_00010000
1098413

Additional References

Wikipedia:Vandetanib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#id
CHEBI:49960
core#notation
CHEBI:49960
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Vandetanib
DRON_00010000
1098413
oboInOwl#hasAlternativeId
CHEBI:49959
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38637
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113776
owl#annotatedSource
t235312
has_treatment
http://purl.obolibrary.org/obo/DOID_6174
owl#someValuesFrom
t1083325