EC 5.99.1.2 (DNA topoisomerase) inhibitor
CHEBI:CHEBI_50276
Definition
A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
Alternative Names
- DNA topoisomerase inhibitor
- DNA topoisomerase inhibitors
- EC 5.99.1.2 (DNA topoisomerase) inhibitors
- EC 5.99.1.2 (topoisomerase I) inhibitor
- EC 5.99.1.2 (topoisomerase I) inhibitors
- EC 5.99.1.2 inhibitor
- EC 5.99.1.2 inhibitors
- topoisomerase I (EC 5.99.1.2) inhibitor
- topoisomerase I (EC 5.99.1.2) inhibitors
- topoisomerase I inhibitor
- topoisomerase I inhibitors
- type I DNA topoisomerase inhibitor
- type I DNA topoisomerase inhibitors
Drug Classification
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topoisomerase inhibitorView Class →
CHEBI:70727
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- core#notation
- CHEBI:50276
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Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- oboInOwl#id
- CHEBI:50276
- core#notation
- CHEBI:50276
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_8988
- owl#someValuesFrom
- t316830
- owl#annotatedSource
- t235135