Discuss This Drug

podophyllotoxin

CHEBI:CHEBI_50305

Definition

An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent. It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts.

Chemical Information

Molecular Formula
C22H22O8
Molecular Mass
414.40530
Charge
0
SMILES
[H][C@]12COC(=O)[C@]1([H])[C@H](c1cc(OC)c(OC)c(OC)c1)c1cc3OCOc3cc1[C@@H]2O
InChI
InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
InChIKey
YJGVMLPVUAXIQN-XVVDYKMHSA-N

Alternative Names

  • (-)-podophyllotoxin
  • (5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
  • 9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE
  • Condylox
  • Podofilox
  • Podophyllinic acid lactone
  • Podophyllotoxin
  • Podophyllotoxin 7
  • PPT

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:50305
DRON_00010000
8463
oboInOwl#hasDbXref
Wikipedia:Podophyllotoxin

Additional References

Wikipedia:Podophyllotoxin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:50305
rxcui
351750
active_ingredient_strength
1 kg/kg
manufacturer_name
Allergan, Inc.
active_ingredient_name
PODOFILOX
nui
N0000008732
pharm_class_pe
Decreased Mitosis [PE]
pharm_class
Decreased Mitosis [PE]
unii
L36H50F353
spl_set_id
032e4bcb-b1ed-4029-b2a6-e92f3bf5cc37
upc
0300236118037
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
8463
oboInOwl#hasDbXref
Wikipedia:Podophyllotoxin
oboInOwl#hasAlternativeId
CHEBI:8280
oboInOwl#id
CHEBI:50305
brand_name
Podofilox
brand_name_base
Podofilox
generic_name
Podofilox
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
labeler_name
Pfanstiehl, Inc.
listing_expiration_date
20241231
dosage_form
GEL
route
TOPICAL
package_marketing_start_date
19970313
marketing_start_date
19970313
product_ndc
0023-6118
spl_id
5c4765c5-397a-48b7-8acc-4d3de0218f44
package_ndc
0023-6118-03
package_description
3.5 g in 1 TUBE, WITH APPLICATOR (0023-6118-03)
application_number
NDA020529
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_61951
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_2071
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_75988
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113361
owl#someValuesFrom
t616026
owl#annotatedSource
t235294