nitisinone
CHEBI:CHEBI_50378
Definition
A cyclohexanone that is cyclohexane-1,3-dione substituted at position 2 by a 2-nitro-4-(trifluoromethyl)benzoyl group. It is used in the treatment of hereditary tyrosinemia type 1.
Chemical Information
- Molecular Formula
- C14H10F3NO5
- Molecular Mass
- 329.22810
- Charge
- 0
- SMILES
- [O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F
- InChI
- InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
- InChIKey
- OUBCNLGXQFSTLU-UHFFFAOYSA-N
Alternative Names
- 2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione
- 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
- nitisinona
- nitisinone
- nitisinonum
- Orfadin
Treatment Applications
-
congenital myasthenic syndrome 17View Disease →
DOID:0110674
-
hypotrichosis 11View Disease →
DOID:0110708
-
nemaline myopathy 2View Disease →
DOID:0110928
-
Joubert syndrome 13View Disease →
DOID:0110982
-
Joubert syndrome 18View Disease →
DOID:0110987
-
glycine N-methyltransferase deficiencyView Disease →
DOID:0111037
-
hawkinsinuriaView Disease →
DOID:0111362
-
steatocystoma multiplexView Disease →
DOID:0111556
-
autosomal dominant woolly hairView Disease →
DOID:0111573
-
velocardiofacial syndromeView Disease →
DOID:12583
-
Jervell-Lange Nielsen syndromeView Disease →
DOID:2842
-
obsolete Verma-Naumoff syndromeView Disease →
DOID:0050551
-
autosomal recessive nonsyndromic deafnessView Disease →
DOID:0050565
-
pontocerebellar hypoplasia type 4View Disease →
DOID:0060273
-
pontocerebellar hypoplasia type 5View Disease →
DOID:0060274
-
Nance-Horan syndromeView Disease →
DOID:0060599
-
hyperekplexia 1View Disease →
DOID:0060696
-
hyperekplexia 3View Disease →
DOID:0060698
-
Norman-Roberts syndromeView Disease →
DOID:0060902
-
X-linked dyskeratosis congenitaView Disease →
DOID:0070025
-
oculocutaneous albinism type IAView Disease →
DOID:0070094
-
oculocutaneous albinism type IBView Disease →
DOID:0070095
-
obsolete Noonan syndrome 6View Disease →
DOID:0070106
-
restrictive dermopathy 1View Disease →
DOID:0070369
-
restrictive dermopathy 2View Disease →
DOID:0070370
-
Watson syndromeView Disease →
DOID:0070483
-
myofibrillar myopathy 7View Disease →
DOID:0080098
-
CAKUT1View Disease →
DOID:0080206
-
Galloway-Mowat syndrome 4View Disease →
DOID:0080246
-
Galloway-Mowat syndrome 5View Disease →
DOID:0080247
-
nephrotic syndrome type 16View Disease →
DOID:0080272
-
Joubert syndrome 32View Disease →
DOID:0080278
-
orofaciodigital syndrome XVIIView Disease →
DOID:0080289
-
trimethylaminuriaView Disease →
DOID:0080361
-
nephrotic syndrome type 1View Disease →
DOID:0080390
-
nephrotic syndrome type 17View Disease →
DOID:0080392
-
nephrotic syndrome type 18View Disease →
DOID:0080393
-
nephrotic syndrome type 19View Disease →
DOID:0080394
-
Cornelia de Lange syndrome 1View Disease →
DOID:0080505
-
Meier-Gorlin syndrome 1View Disease →
DOID:0080512
-
Meier-Gorlin syndrome 2View Disease →
DOID:0080513
-
Meier-Gorlin syndrome 3View Disease →
DOID:0080514
-
hyperprolinemia type 2View Disease →
DOID:0080543
-
congenital disorder of glycosylation IaaView Disease →
DOID:0080553
-
hyper IgE recurrent infection syndrome 2View Disease →
DOID:0080594
-
hyper IgE recurrent infection syndrome 4View Disease →
DOID:0080596
-
anterior segment dysgenesis 2View Disease →
DOID:0080607
-
Stickler syndrome 2View Disease →
DOID:0080675
-
Teebi hypertelorism syndrome 1View Disease →
DOID:0080698
-
Kenny-Caffey syndrome type 1View Disease →
DOID:0080722
-
Brown-Vialetto-Van Laere syndrome 1View Disease →
DOID:0080785
-
Treacher Collins syndrome 1View Disease →
DOID:0080789
-
cranioectodermal dysplasia 1View Disease →
DOID:0080803
-
arthrogryposis multiplex congenita-1View Disease →
DOID:0080978
-
arthrogryposis multiplex congenita-5View Disease →
DOID:0080981
-
congenital myopathy 1BView Disease →
DOID:0080991
-
Cowden syndrome 4View Disease →
DOID:0081000
-
Cowden syndrome 6View Disease →
DOID:0081002
-
acromesomelic dysplasia-4View Disease →
DOID:0081238
-
Smith-McCort dysplasia 1View Disease →
DOID:0081270
-
white sponge nevus 2View Disease →
DOID:0081288
-
congenital myopathy 22AView Disease →
DOID:0081354
-
nemaline myopathy 5BView Disease →
DOID:0081374
-
nemaline myopathy 5CView Disease →
DOID:0081375
-
familial cold autoinflammatory syndrome 1View Disease →
DOID:0090062
-
familial cold autoinflammatory syndrome 2View Disease →
DOID:0090063
-
Leber congenital amaurosis 16View Disease →
DOID:0110118
-
dilated cardiomyopathy 1XView Disease →
DOID:0110444
Drug Classification
-
(trifluoromethyl)benzenesView Class →
CHEBI:83565
-
cyclohexanonesView Class →
CHEBI:23482
-
mesotrioneView Class →
CHEBI:38321
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 61805
- oboInOwl#hasDbXref
- Wikipedia:Nitisinone
- core#notation
- CHEBI:50378
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 61805
- oboInOwl#hasDbXref
- Wikipedia:Nitisinone
- oboInOwl#id
- CHEBI:50378
- core#notation
- CHEBI:50378
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_110001
- has_treatment
- http://purl.obolibrary.org/obo/DOID_0070531
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect26908
- owl#annotatedSource
- t235313
- owl#someValuesFrom
- t3174289