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nitisinone

CHEBI:CHEBI_50378

Definition

A cyclohexanone that is cyclohexane-1,3-dione substituted at position 2 by a 2-nitro-4-(trifluoromethyl)benzoyl group. It is used in the treatment of hereditary tyrosinemia type 1.

Chemical Information

Molecular Formula
C14H10F3NO5
Molecular Mass
329.22810
Charge
0
SMILES
[O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F
InChI
InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
InChIKey
OUBCNLGXQFSTLU-UHFFFAOYSA-N

Alternative Names

  • 2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione
  • 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
  • nitisinona
  • nitisinone
  • nitisinonum
  • Orfadin

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:50378
DRON_00010000
61805
oboInOwl#hasDbXref
Wikipedia:Nitisinone

Additional References

Wikipedia:Nitisinone

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:50378
rxcui
1941476
active_ingredient_strength
1 kg/kg
manufacturer_name
Analog Pharma
nui
N0000190110
pharm_class_moa
Organic Anion Transporter 3 Inhibitors [MoA]
pharm_class
Organic Anion Transporter 3 Inhibitors [MoA]
active_ingredient_name
NITISINONE
pharm_class_epc
4-Hydroxyphenyl-Pyruvate Dioxygenase Inhibitor [EPC]
package_marketing_start_date
26-JUL-17
unii
K5BN214699
spl_set_id
c1b3adc8-02fa-4e22-8c05-8f32b586e53f
upc
0370709005607
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
61805
oboInOwl#hasDbXref
Wikipedia:Nitisinone
oboInOwl#id
CHEBI:50378
generic_name
NITISINONE
brand_name
NITYR
brand_name_base
NITYR
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
CAPSULE
product_ndc
70505-220
application_number
ANDA212390
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
listing_expiration_date
20241231
route
ORAL
labeler_name
Analog Pharma
marketing_start_date
20040817
spl_id
8af3d1e1-0cc0-409f-b665-f0d126ebc82b
package_ndc
70505-220-60
package_description
1 BOTTLE, PLASTIC in 1 CARTON (70505-220-60) / 60 CAPSULE in 1 BOTTLE, PLASTIC
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_110001
has_treatment
http://purl.obolibrary.org/obo/DOID_0070531
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect26908
owl#annotatedSource
t235313
owl#someValuesFrom
t3174289