Discuss This Drug

sorafenib

CHEBI:CHEBI_50924

Definition

A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.

Chemical Information

Molecular Formula
C21H16ClF3N4O3
Molecular Mass
464.826
Charge
0
SMILES
C1(=C(C=C(C=C1)NC(NC2=CC=C(C=C2)OC3=CC=NC(=C3)C(NC)=O)=O)C(F)(F)F)Cl
InChI
InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
InChIKey
MLDQJTXFUGDVEO-UHFFFAOYSA-N

Alternative Names

  • 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
  • 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
  • N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
  • sorafenib
  • sorafenibum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
495881
oboInOwl#hasDbXref
Wikipedia:Sorafenib
core#notation
CHEBI:50924

Additional References

Wikipedia:Sorafenib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
route
ORAL
marketing_start_date
20231002
package_marketing_start_date
09-NOV-22
spl_id
7fe088d2-a4a3-4a3c-947a-a4e0bc667bdc
package_ndc
86184-366-01
package_description
1 g in 1 PACKAGE (86184-366-01)
labeler_name
Patheon France S.A.S
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
495881
oboInOwl#hasDbXref
Wikipedia:Sorafenib
oboInOwl#hasAlternativeId
CHEBI:47228
oboInOwl#id
CHEBI:50924
generic_name
sorafenib tosylate
brand_name
Nexavar
brand_name_base
Nexavar
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
POWDER
product_ndc
86184-366
application_number
ANDA207012
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_173085
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:50924
rxcui
615979
active_ingredient_strength
50 kg/50kg
nui
N0000175076
pharm_class_epc
Kinase Inhibitor [EPC]
pharm_class
Protein Kinase Inhibitors [MoA]
pharm_class_moa
Protein Kinase Inhibitors [MoA]
manufacturer_name
TWi Pharmaceuticals USA, Inc.
active_ingredient_name
SORAFENIB TOSYLATE
unii
5T62Q3B36J
spl_set_id
68aa4b7f-3f13-4e73-b572-aa6c11a8429c
upc
0324979715445
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0081416
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect27411
owl#annotatedSource
t238477
owl#someValuesFrom
t960766