Dutasteride
CHEBI:CHEBI_521033
Definition
An aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Dutasteride is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland.
Chemical Information
- Molecular Formula
- C27H30F6N2O2
- Molecular Mass
- 528.531
- Charge
- 0
- SMILES
- C=1C(N[C@]2([C@@](C1)(C)[C@]3(CC[C@@]4([C@](CC[C@]4([C@]3([H])CC2)[H])(C(=O)NC5=CC(=CC=C5C(F)(F)F)C(F)(F)F)[H])C)[H])[H])=O
- InChI
- InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1
- InChIKey
- JWJOTENAMICLJG-QWBYCMEYSA-N
Alternative Names
- (5alpha,17beta)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
- alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide
- N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
Drug Classification
-
(trifluoromethyl)benzenesView Class →
CHEBI:83565
-
delta-lactamView Class →
CHEBI:77727
-
aza-steroidView Class →
CHEBI:35726
-
t241215
-
t241861
-
t242181
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 228790
- oboInOwl#hasDbXref
- Wikipedia:Dutasteride
- core#notation
- CHEBI:521033
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- marketing_category
- EXPORT ONLY
- listing_expiration_date
- 20241231
- labeler_name
- Waylis Therapeutics
- marketing_start_date
- 20011120
- product_type
- HUMAN PRESCRIPTION DRUG
- spl_id
- a2d8fb54-19ab-e450-e053-2a95a90ab1e9
- application_number
- ANDA213300
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 228790
- oboInOwl#hasDbXref
- Wikipedia:Dutasteride
- oboInOwl#id
- CHEBI:521033
- generic_name
- DUTASTERIDE and TAMSULOSIN HYDROCHLORIDE
- brand_name
- Jalyn
- brand_name_base
- Jalyn
- dosage_form
- CAPSULE, GELATIN COATED
- product_ndc
- 59057-005
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_50781
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#has_parent_hydride
- http://purl.obolibrary.org/obo/CHEBI_28859
- route
- ORAL
- package_ndc
- 59057-005-00
- manufacturer_name
- Waylis Therapeutics
- package_marketing_start_date
- 20-NOV-15
- package_description
- 10000 CAPSULE, LIQUID FILLED in 1 BOX (10888-8101-1)
- core#notation
- CHEBI:521033
- rxcui
- 996101
- active_ingredient_strength
- 25 kg/25kg
- nui
- N0000000126
- pharm_class_epc
- 5-alpha Reductase Inhibitor [EPC]
- pharm_class
- alpha-Adrenergic Blocker [EPC]
- pharm_class_moa
- 5-alpha Reductase Inhibitors [MoA]
- active_ingredient_name
- DUTASTERIDE
- unii
- O0J6XJN02I
- spl_set_id
- f95c3fff-1e15-4ab8-a839-6a65a5828dbb
- upc
- 0372865140901
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- has_treatment
- http://purl.obolibrary.org/obo/DOID_2989
- owl#annotatedSource
- t242279
- owl#someValuesFrom
- t1054121