donepezil
CHEBI:CHEBI_53289
Definition
A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
Chemical Information
- Molecular Formula
- C24H29NO3
- Molecular Mass
- 379.500
- Charge
- 0
- SMILES
- C1(=C(C=C2C(=C1)CC(C2=O)(CC3CCN(CC3)CC4=CC=CC=C4)[H])OC)OC
- InChI
- InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
- InChIKey
- ADEBPBSSDYVVLD-UHFFFAOYSA-N
Alternative Names
- donepezil
- donepezilo
- donepezilum
Treatment Applications
-
congenital myasthenic syndrome 5View Disease →
DOID:0110667
Drug Classification
-
racemateView Class →
CHEBI:60911
-
t244662
-
t244742
-
t245027
-
t245412
-
t245537
-
t245667
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 135447
- oboInOwl#hasDbXref
- Wikipedia:Donepezil
- core#notation
- CHEBI:53289
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- listing_expiration_date
- 20241231
- marketing_start_date
- 20041024
- labeler_name
- Curia Italy S.r.l.
- spl_id
- 02e5b533-6892-8784-7b7f-4eb924c4e9c8
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
- dosage_form
- TABLET, ORALLY DISINTEGRATING
- application_number
- NDA022568
- product_ndc
- 68180-527
- route
- TRANSDERMAL
- package_ndc
- 72189-265-90
- package_description
- 30 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (43547-275-03)
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 135447
- oboInOwl#hasDbXref
- Wikipedia:Donepezil
- oboInOwl#id
- CHEBI:53289
- generic_name
- Donepezil Hydrochloride Monohydrate (Form-1)
- brand_name
- Aricept
- brand_name_base
- Aricept
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_38462
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#is_conjugate_base_of
- http://purl.obolibrary.org/obo/CHEBI_145498
- BFO_0000051
- http://purl.obolibrary.org/obo/CHEBI_53292
- core#notation
- CHEBI:53289
- active_ingredient_strength
- 23 mg/1
- pharm_class
- Cholinesterase Inhibitors [MoA]
- active_ingredient_name
- DONEPEZIL
- upc
- 0368382521019
- spl_set_id
- c777ddc9-0b61-4d6f-95d6-818ba1861d62
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- manufacturer_name
- Corium, LLC.
- package_marketing_start_date
- 24-OCT-04
- rxcui
- 2597459
- unii
- 3O2T2PJ89D
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_105018
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect6533
- chebi#is_conjugate_acid_of
- http://purl.obolibrary.org/obo/CHEBI_145498
- owl#someValuesFrom
- t3866246
- owl#annotatedSource
- t245760