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Granisetron

CHEBI:CHEBI_5537

Definition

A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 1-methyl-1H-indazole-3-carboxylic acid with the primary amino group of (3-endo)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine. A selective 5-HT3 receptor antagonist, it is used (generally as the monohydrochloride salt) to manage nausea and vomiting caused by cancer chemotherapy and radiotherapy, and to prevent and treat postoperative nausea and vomiting.

Chemical Information

Molecular Formula
C18H24N4O
Molecular Mass
312.40940
Charge
0
SMILES
CN1[C@H]2CCC[C@@H]1C[C@@H](C2)NC(=O)c1nn(C)c2ccccc12
InChI
InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13+,14-
InChIKey
MFWNKCLOYSRHCJ-BTTYYORXSA-N

Alternative Names

  • 1-methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide
  • 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
  • APF 530
  • APF530
  • BRL 43694
  • granisetron
  • granisetronum
  • Kevatril
  • Sancuso
  • Sustol

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:5537
DRON_00010000
26237
oboInOwl#hasDbXref
Wikipedia:Granisetron

Additional References

Wikipedia:Granisetron

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:5537
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
26237
oboInOwl#hasDbXref
Wikipedia:Granisetron
oboInOwl#id
CHEBI:5537
generic_name
Granisetron hydrochloride
brand_name
Granisetron hydrochloride
brand_name_base
Granisetron hydrochloride
product_ndc
14778-0202
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50919
rxcui
1734399
active_ingredient_strength
10 mg/.4mL
manufacturer_name
Natco Pharma Limited
pharm_class
Serotonin 3 Receptor Antagonists [MoA]
package_marketing_start_date
04-APR-06
active_ingredient_name
GRANISETRON
package_description
1 kg in 1 PACKAGE (14778-0202-1)
unii
318F6L70J8
spl_set_id
d2be8de3-04fe-4e92-82b4-98d749b89596
upc
0363323318017
package_ndc
64567-0010-0
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
owl#annotatedSource
t249184
owl#someValuesFrom
t3046716
product_type
BULK INGREDIENT
listing_expiration_date
20241231
route
INTRAVENOUS
dosage_form
INJECTION, SOLUTION
marketing_category
BULK INGREDIENT
labeler_name
Isomedix Operations
marketing_start_date
20051030
application_number
ANDA091137
spl_id
cc864e1f-201d-486a-e053-2a95a90a89dc