Discuss This Drug

Cladribine

CHEBI:CHEBI_567361

Definition

2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.

Chemical Information

Molecular Formula
C10H12ClN5O3
Molecular Mass
285.68700
Charge
0
SMILES
Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1
InChI
InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
InChIKey
PTOAARAWEBMLNO-KVQBGUIXSA-N

Alternative Names

  • (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
  • 2-CdA
  • 2-chloro-2'-deoxy-beta-adenosine
  • 2-chloro-2'-deoxyadenosine
  • 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine
  • 2-chloro-deoxyadenosine
  • 2-chlorodeoxyadenosine
  • 2ClAdo
  • cladribina
  • cladribine
  • Cladribine
  • cladribinum
  • CldAdo

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:567361
oboInOwl#hasDbXref
Wikipedia:Cladribine
DRON_00010000
44157

Additional References

Wikipedia:Cladribine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:567361
rxcui
2122661
package_marketing_start_date
22-APR-04
active_ingredient_strength
25 kg/25kg
manufacturer_name
EMD Serono, Inc.
route
ORAL
nui
N0000175712
pharm_class_epc
Purine Antimetabolite [EPC]
pharm_class
Purine Antimetabolite [EPC]
active_ingredient_name
CLADRIBINE
package_ndc
12502-5406-7
package_description
10 kg in 1 DRUM (12502-5406-7)
unii
47M74X9YT5
spl_set_id
9c75e30a-a410-40f1-b653-04d532bd9144
upc
0363323140106
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Cladribine
DRON_00010000
44157
oboInOwl#hasAlternativeId
CHEBI:568373
oboInOwl#id
CHEBI:567361
generic_name
Cladribine Cyclodextrin
brand_name
Mavenclad
brand_name_base
Mavenclad
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
INJECTION
marketing_start_date
20000228
labeler_name
Cilag AG
product_ndc
12502-5406
application_number
NDA022561
spl_id
b5e6ed4c-0fc7-3e32-e053-2995a90a14cf
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35705
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_357
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect28969
owl#annotatedSource
t249154
owl#someValuesFrom
t3389964