Felodipine
CHEBI:CHEBI_585948
Definition
The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
Chemical Information
- Molecular Formula
- C18H19Cl2NO4
- Molecular Mass
- 384.25400
- Charge
- 0
- SMILES
- CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(Cl)c1Cl)C(=O)OC
- InChI
- InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
- InChIKey
- RZTAMFZIAATZDJ-UHFFFAOYSA-N
Alternative Names
- (+-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
- 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
- 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
- ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- felodipina
- felodipine
- FELODIPINE
- felodipinum
Drug Classification
-
dihydropyridineView Class →
CHEBI:50075
-
ethyl esterView Class →
CHEBI:23990
-
methyl esterView Class →
CHEBI:25248
-
dichlorobenzeneView Class →
CHEBI:23697
-
DichlorobenzeneView Class →
CHEBI:23697
-
t251346
-
t251611
-
t251668
-
t252093
-
t252557
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 4316
- oboInOwl#hasDbXref
- Wikipedia:Felodipine
- core#notation
- CHEBI:585948
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 4316
- oboInOwl#hasDbXref
- Wikipedia:Felodipine
- oboInOwl#hasAlternativeId
- CHEBI:4996
- oboInOwl#id
- CHEBI:585948
- generic_name
- Felodipine Extended-release Tablets
- brand_name
- Felopdipine
- brand_name_base
- Felopdipine
- product_ndc
- 71205-920
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_38215
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- BFO_0000053
- http://purl.obolibrary.org/obo/DRON_00020325
- product_type
- BULK INGREDIENT
- listing_expiration_date
- 20241231
- marketing_category
- BULK INGREDIENT
- labeler_name
- Yiling Pharmaceutical Inc.
- dosage_form
- TABLET, FILM COATED, EXTENDED RELEASE
- marketing_start_date
- 20100402
- application_number
- ANDA090365
- spl_id
- 94eca4d7-4fe9-4729-b67b-b99d31b46917
- route
- ORAL
- package_ndc
- 71205-920-90
- package_description
- 90 TABLET, FILM COATED in 1 BOTTLE (71205-920-90)
- manufacturer_name
- Yiling Pharmaceutical Inc.
- package_marketing_start_date
- 02-APR-10
- has_treatment
- http://purl.obolibrary.org/obo/DOID_10300
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect29208
- owl#annotatedSource
- t252654
- owl#someValuesFrom
- t3000630
- core#notation
- CHEBI:585948
- active_ingredient_name
- FELODIPINE
- rxcui
- 402698
- active_ingredient_strength
- 40 kg/40kg
- pharm_class_moa
- Calcium Channel Antagonists [MoA]
- pharm_class
- Dihydropyridines [CS]
- nui
- M0006414
- pharm_class_epc
- Dihydropyridine Calcium Channel Blocker [EPC]
- pharm_class_cs
- Dihydropyridines [CS]
- unii
- OL961R6O2C
- spl_set_id
- 78341a0a-1274-417e-ae69-e133ee0480f9
- upc
- 0323155049015
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class