Amorolfine
CHEBI:CHEBI_599440
Definition
A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections.
Chemical Information
- Molecular Formula
- C21H35NO
- Molecular Mass
- 317.50870
- Charge
- 0
- SMILES
- CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1
- InChI
- InChI=1S/C21H35NO/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22/h8-11,16-18H,7,12-15H2,1-6H3/t16?,17-,18+
- InChIKey
- MQHLMHIZUIDKOO-AYHJJNSGSA-N
Alternative Names
- (+-)-cis-2,6-dimethyl-4-(2-methyl-3-(p-tert-pentylphenyl)propyl)morpholine
- (2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine
- amorolfina
- amorolfine
- amorolfinum
- meso-2,6-dimethyl-4-(2-methyl-3-(p-tert-pentylphenyl)propyl)morpholine
- meso-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine
Drug Classification
-
morpholine antifungal drugView Class →
CHEBI:87135
-
tertiary amino compoundView Class →
CHEBI:50996
-
t255160
-
t255176
-
t255271
-
t255745
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 17804
- oboInOwl#hasDbXref
- Wikipedia:Amorolfine
- core#notation
- CHEBI:599440
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 17804
- oboInOwl#hasDbXref
- Wikipedia:Amorolfine
- oboInOwl#hasAlternativeId
- CHEBI:31779
- oboInOwl#id
- CHEBI:599440
- core#notation
- CHEBI:599440
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_83319
- chebi#is_conjugate_acid_of
- http://purl.obolibrary.org/obo/CHEBI_86380
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- has_treatment
- http://purl.obolibrary.org/obo/DOID_0050294
- chebi#is_conjugate_base_of
- http://purl.obolibrary.org/obo/CHEBI_86380
- owl#annotatedSource
- t256053
- owl#someValuesFrom
- t568119