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Amorolfine

CHEBI:CHEBI_599440

Definition

A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections.

Chemical Information

Molecular Formula
C21H35NO
Molecular Mass
317.50870
Charge
0
SMILES
CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1
InChI
InChI=1S/C21H35NO/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22/h8-11,16-18H,7,12-15H2,1-6H3/t16?,17-,18+
InChIKey
MQHLMHIZUIDKOO-AYHJJNSGSA-N

Alternative Names

  • (+-)-cis-2,6-dimethyl-4-(2-methyl-3-(p-tert-pentylphenyl)propyl)morpholine
  • (2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine
  • amorolfina
  • amorolfine
  • amorolfinum
  • meso-2,6-dimethyl-4-(2-methyl-3-(p-tert-pentylphenyl)propyl)morpholine
  • meso-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
17804
oboInOwl#hasDbXref
Wikipedia:Amorolfine
core#notation
CHEBI:599440

Additional References

Wikipedia:Amorolfine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

has_treatment
http://purl.obolibrary.org/obo/DOID_0050294
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_86380
owl#annotatedSource
t256053
owl#someValuesFrom
t568119
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
17804
oboInOwl#hasDbXref
Wikipedia:Amorolfine
oboInOwl#hasAlternativeId
CHEBI:31779
oboInOwl#id
CHEBI:599440
core#notation
CHEBI:599440
rxcui
250968
listing_expiration_date
20251231
route
TOPICAL
product_type
HUMAN OTC DRUG
marketing_category
OTC MONOGRAPH DRUG
dosage_form
LIQUID
marketing_start_date
20241031
package_marketing_start_date
20241031
active_ingredient_strength
5 g/100mL
application_number
M005
generic_name
amorolfine hydrochloride
brand_name
Amorophen hydrochloride liniment
brand_name_base
Amorophen hydrochloride liniment
product_ndc
84534-002
labeler_name
ZheJiang Longmed Medical Technology Co., Ltd.
manufacturer_name
ZheJiang Longmed Medical Technology Co., Ltd.
spl_id
25c097cf-481b-d59a-e063-6294a90a9a39
active_ingredient_name
AMOROLFINE HYDROCHLORIDE
package_ndc
84534-002-06
package_description
30 mL in 1 BOTTLE (84534-002-06)
unii
741YH7379H
spl_set_id
25c097cf-481a-d59a-e063-6294a90a9a39
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_83319
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_86380
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class