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Daptomycin

CHEBI:CHEBI_600103

Definition

A polypeptide comprising N-decanoyltryptophan, asparagine, aspartic acid, threonine, glycine, ornithine, aspartic acid, D-alanine, aspartic acid, glycine, D-serine, threo-3-methylglutamic acid and 3-anthraniloylalanine (also known as kynurinine) coupled in sequence and lactonised by condensation of the carboxylic acid group of the 3-anthraniloylalanine with the alcohol group of the threonine residue.

Chemical Information

Molecular Formula
C72H101N17O26
Molecular Mass
1620.67060
Charge
0
SMILES
CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](CC(=O)c2ccccc2N)NC(=O)[C@@H](NC(=O)[C@@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN)NC(=O)CNC1=O)[C@H](C)CC(O)=O
InChI
InChI=1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43+,44+,45+,46+,47+,48+,49+,50-,60+,61+/m1/s1
InChIKey
DOAKLVKFURWEDJ-RWDRXURGSA-N

Alternative Names

  • Cidecin
  • Cubicin
  • daptomicina
  • daptomycin
  • daptomycin
  • Daptomycin
  • daptomycine
  • daptomycinum
  • LY 146032
  • N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone
  • N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone
  • N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
22299
oboInOwl#hasDbXref
Wikipedia:Daptomycin
core#notation
CHEBI:600103

Additional References

Wikipedia:Daptomycin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
route
INTRAVENOUS
marketing_start_date
20241025
spl_id
f23eb777-6de7-4b66-8fe9-1f0a70e7f225
package_ndc
70594-066-01
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
22299
oboInOwl#hasDbXref
Wikipedia:Daptomycin
oboInOwl#hasAlternativeId
CHEBI:478255
oboInOwl#id
CHEBI:600103
generic_name
Daptomycin in Sodium Chloride
brand_name
DAPZURA RT
brand_name_base
DAPZURA RT
product_ndc
70594-066
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_140190
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
rxcui
2591793
package_marketing_start_date
28-OCT-20
manufacturer_name
Aspiro Pharma Limited
unii
NWQ5N31VKK
spl_set_id
74c9700f-80b5-4665-88ca-1814c0150a29
package_description
10 VIAL, SINGLE-DOSE in 1 CARTON (43598-476-58) / 7 mL in 1 VIAL, SINGLE-DOSE
core#notation
CHEBI:600103
active_ingredient_strength
700 mg/100mL
active_ingredient_name
DAPTOMYCIN
pharm_class
Lipopeptide Antibacterial [EPC]
pharm_class_cs
Lipopeptides [CS]
nui
M0519359
upc
0343598413112
pharm_class_epc
Lipopeptide Antibacterial [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
labeler_name
Aspiro Pharma Limited
application_number
ANDA211403
has_treatment
http://purl.obolibrary.org/obo/DOID_2176
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect29710
owl#annotatedSource
t256041
owl#someValuesFrom
t2990433