Discuss This Drug

Isotretinoin

CHEBI:CHEBI_6067

Definition

A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.

Chemical Information

Molecular Formula
C20H28O2
Molecular Mass
300.43512
Charge
0
SMILES
CC(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(C)=C\C(O)=O
InChI
InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-
InChIKey
SHGAZHPCJJPHSC-XFYACQKRSA-N

Alternative Names

  • (2Z,4E6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
  • (7E,9E,11E,13Z)-retinoic acid
  • 13-cis-retinoic acid
  • 13-cis-Vitamin A acid
  • 13-RA
  • Accutane
  • Amnesteem
  • cis-RA
  • Claravis
  • isotretinoin
  • isotretinoina
  • isotretinoine
  • isotretinoino
  • isotretinoinum
  • Neovitamin A acid

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
6064
oboInOwl#hasDbXref
Wikipedia:Isotretinoin
core#notation
CHEBI:6067

Additional References

Wikipedia:Isotretinoin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
6064
brand_name
Absorica
brand_name_base
Absorica
oboInOwl#hasDbXref
Wikipedia:Isotretinoin
oboInOwl#id
CHEBI:6067
generic_name
Isotretinoin M
product_ndc
10631-134
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50905
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_169952
rxcui
2473107
active_ingredient_strength
24 mg/1
manufacturer_name
JG Pharma Inc.
package_marketing_start_date
20230912
active_ingredient_name
ISOTRETINOIN
unii
EH28UP18IF
spl_set_id
c2917c3d-3499-48a0-ba53-120cb979195d
package_description
3 BLISTER PACK in 1 BOX (10631-134-31) / 10 CAPSULE in 1 BLISTER PACK (10631-134-69)
package_ndc
76055-0010-1
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
CAPSULE, GELATIN COATED
marketing_start_date
19820507
labeler_name
Catalent France Beinheim S.A
application_number
ANDA207792
listing_expiration_date
20241231
route
ORAL
spl_id
96869be5-59f0-ade9-e053-2995a90a1954
core#notation
CHEBI:6067
nui
M0018962
pharm_class_epc
Retinoid [EPC]
pharm_class
Retinoids [CS]
pharm_class_cs
Retinoids [CS]
upc
0369238101713
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0070523
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113429
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_169952
owl#someValuesFrom
t879271
owl#annotatedSource
t256055