Discuss This Drug

romidepsin

CHEBI:CHEBI_61080

Definition

A cyclodepsipeptide consisting of the cyclic disulfide of (2Z)-2-aminobut-2-enoyl, L-valyl, (3S,4E)-3-hydroxy-7-sulfanylhept-4-enoyl, D-valyl and D-cysteinyl residues coupled in sequence and cyclised head-to tail.

Chemical Information

Molecular Formula
C24H36N4O6S2
Molecular Mass
540.69600
Charge
0
SMILES
C\C=C1/NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C
InChI
InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1
InChIKey
OHRURASPPZQGQM-GCCNXGTGSA-N

Alternative Names

  • (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
  • Antibiotic FR 901228
  • Chromadax
  • FK228
  • FR901228
  • Istodax
  • NSC-630176
  • romidepsin
  • romidepsina
  • romidepsine
  • romidepsinum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:61080
DRON_00010000
877510
oboInOwl#hasDbXref
Wikipedia:Romidepsin

Additional References

Wikipedia:Romidepsin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:61080
nui
N0000190110
pharm_class_moa
Histone Deacetylase Inhibitors [MoA]
pharm_class
Histone Deacetylase Inhibitors [MoA]
active_ingredient_strength
1 kg/kg
pharm_class_epc
Histone Deacetylase Inhibitor [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
877510
oboInOwl#hasDbXref
Wikipedia:Romidepsin
oboInOwl#id
CHEBI:61080
oboInOwl#hasAlternativeId
CHEBI:69482
generic_name
Romidepsin
rxcui
2289413
dosage_form
INJECTION, SOLUTION, CONCENTRATE
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
INTRAVENOUS
marketing_start_date
20190123
labeler_name
Celgene Corporation
manufacturer_name
Celgene Corporation
package_marketing_start_date
23-JAN-19
brand_name
ISTODAX
brand_name_base
ISTODAX
product_ndc
54893-0083
spl_id
0cdc6463-bc8b-e6ca-e063-6394a90a6ac3
active_ingredient_name
ROMIDEPSIN
package_ndc
54893-0083-6
package_description
3 kg in 1 DRUM (54893-0083-6)
application_number
NDA208574
spl_set_id
a0478684-e477-4b52-97a9-04a76e794c87
unii
CX3T89XQBK
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_61115
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect29986
owl#annotatedSource
t259416
owl#someValuesFrom
t2916400