Discuss This Drug

Ketorolac

CHEBI:CHEBI_6129

Definition

A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.

Chemical Information

Molecular Formula
C15H13NO3
Molecular Mass
255.269
Charge
0
SMILES
N12C(C(C(=O)O)CC1)=CC=C2C(=O)C3=CC=CC=C3
InChI
InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
InChIKey
OZWKMVRBQXNZKK-UHFFFAOYSA-N

Alternative Names

  • (+-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • (+-)-ketorolac
  • ketorolac
  • ketorolaco
  • ketorolacum
  • rac-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • rac-ketorolac

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Ketorolac
DRON_00010000
35827
core#notation
CHEBI:6129

Additional References

Wikipedia:Ketorolac

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

route
NASAL
package_ndc
38779-2249-9
spl_id
39ecb178-ee03-7a90-7348-5bd3308208d8
dosage_form
SPRAY, METERED
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
application_number
NDA022382
product_ndc
61314-126
listing_expiration_date
20241231
marketing_start_date
20230719
package_description
25 VIAL in 1 CARTON (72266-234-25) / 1 mL in 1 VIAL (72266-234-01)
manufacturer_name
DR. REDDY'S LABORATORIES, INC.
package_marketing_start_date
01-JAN-00
labeler_name
DR. REDDY'S LABORATORIES, INC.
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Ketorolac
DRON_00010000
35827
oboInOwl#id
CHEBI:6129
generic_name
Ketorolac Tromethamine, Lidocaine Hydrochloride, Povidine Iodine
brand_name
Ketorocaine L Kit
brand_name_base
Ketorocaine L Kit
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50630
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_76228
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_76229
core#notation
CHEBI:6129
pharm_class
Cyclooxygenase Inhibitor [EPC]
upc
0368462757024
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rxcui
1737568
spl_set_id
b6364505-1043-fe12-e053-2995a90a6f40
unii
4EVE5946BQ
active_ingredient_strength
15.75 mg/1
active_ingredient_name
KETOROLAC TROMETHAMINE
has_treatment
http://purl.obolibrary.org/obo/DOID_11204
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect30140
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_76229
owl#annotatedSource
t259508
owl#someValuesFrom
t3019993