Discuss This Drug

neratinib

CHEBI:CHEBI_61397

Definition

A quinoline compound having a cyano group at the 3-position, a 3-chloro-4-(2-pyridylmethoxy)anilino group at the 4-position, a 4-dimethylamino-trans-but-2-enoylamido group at the 6-position, and an ethoxy group at the 7-position.

Chemical Information

Molecular Formula
C30H29ClN6O3
Molecular Mass
557.050
Charge
0
SMILES
C1(=C(C=C2C(=C1)C(=C(C=N2)C#N)NC3=CC=C(C(=C3)Cl)OCC4=NC=CC=C4)OCC)NC(/C=C/CN(C)C)=O
InChI
InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+
InChIKey
JWNPDZNEKVCWMY-VQHVLOKHSA-N

Alternative Names

  • (2E)-N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
  • HKI 272
  • HKI-272
  • N-(4-(3-Chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide
  • neratinib

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1940643
oboInOwl#hasDbXref
Reaxys:9971763
core#notation
CHEBI:61397

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

has_treatment
http://purl.obolibrary.org/obo/DOID_0060079
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chebi_ontology
DRON_00010000
1940643
oboInOwl#hasDbXref
Reaxys:9971763
oboInOwl#id
CHEBI:61397
core#notation
CHEBI:61397
generic_name
Neratinib Maleate
rxcui
1940654
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
POWDER
pharm_class
Kinase Inhibitors [MoA]
active_ingredient_strength
5 kg/5kg
marketing_start_date
20230515
package_marketing_start_date
15-MAY-23
labeler_name
Pliva Hrvatska d.o.o.
brand_name
Nerlynx
brand_name_base
Nerlynx
product_ndc
11722-079
application_number
NDA208051
manufacturer_name
Puma Biotechnology, Inc.
spl_id
f2b16ab2-2fd0-434d-9e28-aae252bebcb0
active_ingredient_name
NERATINIB MALEATE
package_ndc
11722-079-00
package_description
5 kg in 1 CARTON (11722-079-00)
unii
9RM7XY23ZS
spl_set_id
d1e41dcf-e82a-47c2-a0ad-6c6eef621834
upc
0370437240264
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38637
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
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http://www.w3.org/2002/07/owl#Class