Discuss This Drug

cabazitaxel

CHEBI:CHEBI_63584

Definition

A tetracyclic diterpenoid that is 10-deacetylbaccatin III having O-methyl groups attached at positions 7 and 10 as well as an O-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl group attached at position 13. Acts as a microtubule inhibitor, binds tubulin and promotes microtubule assembly and simultaneously inhibits disassembly.

Chemical Information

Molecular Formula
C45H57NO14
Molecular Mass
835.93240
Charge
0
SMILES
[H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](OC)C(=O)[C@]1(C)[C@H](C[C@H]1OC[C@@]21OC(C)=O)OC)C3(C)C
InChI
InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1
InChIKey
BMQGVNUXMIRLCK-OAGWZNDDSA-N

Alternative Names

  • (2alpha,5beta,7beta,10beta,13alpha)-4-acetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
  • cabazitaxel
  • cabazitaxelum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:63584
DRON_00010000
996051
oboInOwl#hasDbXref
Wikipedia:Cabazitaxel

Additional References

Wikipedia:Cabazitaxel

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:63584
rxcui
1376084
active_ingredient_strength
100 kg/100kg
manufacturer_name
Sanofi-Aventis U.S. LLC
package_marketing_start_date
14-MAY-15
active_ingredient_name
CABAZITAXEL
spl_set_id
de3d9c26-572b-4ea4-9b2d-dd58a2b3e8fa
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
996051
generic_name
Cabazitaxel
oboInOwl#hasDbXref
Wikipedia:Cabazitaxel
oboInOwl#id
CHEBI:63584
dosage_form
POWDER, FOR SUSPENSION
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
listing_expiration_date
20241231
marketing_start_date
20100617
labeler_name
Yung Shin Pharm. Ind. Co., Ltd.
product_ndc
0024-5824
spl_id
5a02651b-22cf-4ca3-985d-d0f2f391c26f
package_ndc
0024-5824-11
package_description
1 KIT in 1 CARTON (0024-5824-11) * 5.7 mL in 1 VIAL, GLASS (0024-5823-15) * 5.7 mL in 1 VIAL, GLASS (0024-5822-01)
brand_name
Jevtana
brand_name_base
Jevtana
application_number
NDA201023
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_61950
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_18193
has_treatment
http://purl.obolibrary.org/obo/DOID_2992
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect30437
owl#annotatedSource
t262956
owl#someValuesFrom
t3055748