Discuss This Drug

ixabepilone

CHEBI:CHEBI_63605

Definition

A macrocycle that is a lactam analogue of epothilone B. Binds directly to beta-tubulin subunits on microtubules, leading to suppression of microtubule dynamics.

Chemical Information

Molecular Formula
C27H42N2O5S
Molecular Mass
506.69800
Charge
0
SMILES
[H][C@]12C[C@H](NC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC[C@@]1(C)O2)C(\C)=C\c1csc(C)n1
InChI
InChI=1S/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
InChIKey
FABUFPQFXZVHFB-PVYNADRNSA-N

Alternative Names

  • Aza-epothilone B
  • Azaepothilone B
  • BMS-247550
  • ixabepilone

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
337523
oboInOwl#hasDbXref
Wikipedia:Ixabepilone
core#notation
CHEBI:63605

Additional References

Wikipedia:Ixabepilone

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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oboInOwl#id
CHEBI:63605
core#notation
CHEBI:63605
generic_name
Ixabepilone
rxcui
1726278
dosage_form
POWDER
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
INTRAVENOUS
active_ingredient_strength
1 kg/kg
marketing_start_date
20140926
package_marketing_start_date
30-JUN-21
labeler_name
Hubei HONCH Pharmaceutical Co., Ltd.
product_ndc
70020-1910
spl_id
f263af58-0351-1054-e053-2995a90a581b
active_ingredient_name
(Z)-IXABEPILONE
package_ndc
70020-1910-1
package_description
1 KIT in 1 PACKAGE, COMBINATION (70020-1910-1) * 15 mg in 1 VIAL, SINGLE-USE * 8 mL in 1 VIAL, SINGLE-USE
brand_name
IXEMPRA
brand_name_base
IXEMPRA
application_number
NDA022065
manufacturer_name
R-Pharm US Operating, LLC
spl_set_id
241f0b1e-8b95-470d-876f-bf1804daaf18
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_61951
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