Discuss This Drug

nelarabine

CHEBI:CHEBI_63612

Definition

A purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G).

Chemical Information

Molecular Formula
C11H15N5O5
Molecular Mass
297.26730
Charge
0
SMILES
COc1nc(N)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
InChI
InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1
InChIKey
IXOXBSCIXZEQEQ-UHTZMRCNSA-N

Alternative Names

  • 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine
  • 9-(beta-D-arabinofuranosyl)-6-methoxy-9H-purin-2-amine
  • Arranon
  • nelzarabine
  • Nelzarabine

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
274771
oboInOwl#hasDbXref
Reaxys:13568768
core#notation
CHEBI:63612

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
marketing_start_date
20140909
route
INTRAVENOUS
spl_id
a58ed38e-0f37-4864-a8b7-f796ce5fc30d
package_ndc
71288-165-54
package_description
1 VIAL, SINGLE-DOSE in 1 CARTON (71288-165-54) / 50 mL in 1 VIAL, SINGLE-DOSE (71288-165-52)
labeler_name
ScinoPharm Taiwan Ltd.
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
274771
brand_name
Nelarabine
brand_name_base
Nelarabine
oboInOwl#hasDbXref
Reaxys:13568768
oboInOwl#id
CHEBI:63612
generic_name
nelarabine injection
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, SOLUTION
product_ndc
71288-165
application_number
ANDA216038
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50266
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_73141
core#notation
CHEBI:63612
rxcui
616366
pharm_class_moa
Nucleic Acid Synthesis Inhibitors [MoA]
pharm_class
Nucleoside Metabolic Inhibitor [EPC]
pharm_class_epc
Nucleoside Metabolic Inhibitor [EPC]
active_ingredient_strength
250 mg/50mL
manufacturer_name
AqVida GmbH
package_marketing_start_date
09-SEP-14
nui
N0000175595
active_ingredient_name
NELARABINE
unii
60158CV180
spl_set_id
21919314-5c25-49ab-beba-099983ed4a71
upc
0314789114071
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_5599
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect30570
owl#annotatedSource
t262955
owl#someValuesFrom
t2910435