pemetrexed
CHEBI:CHEBI_63616
Definition
An N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
Chemical Information
- Molecular Formula
- C20H21N5O6
- Molecular Mass
- 427.41060
- Charge
- 0
- SMILES
- Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c[nH]c2[nH]1
- InChI
- InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1
- InChIKey
- WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
Alternative Names
- N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid
- pemetrexed
Drug Classification
-
pyrrolopyrimidineView Class →
CHEBI:38670
-
N-acyl-L-glutamic acidView Class →
CHEBI:21650
-
t261673
-
t261976
-
t262055
-
t262133
-
t262884
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- oboInOwl#hasDbXref
- Wikipedia:Pemetrexed
- DRON_00010000
- 68446
- core#notation
- CHEBI:63616
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- route
- INTRAVENTRICULAR
- package_ndc
- 55111-919-00
- spl_id
- c75eae86-fead-40b1-861a-0af1f27b3263
- package_description
- 1 kg in 1 DRUM (55111-919-00)
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT
- dosage_form
- SOLUTION, CONCENTRATE
- application_number
- NDA208419
- product_ndc
- 70121-2462
- listing_expiration_date
- 20241231
- marketing_start_date
- 20070907
- labeler_name
- Shilpa Medicare Limited
- oboInOwl#hasOBONamespace
- chebi_ontology
- oboInOwl#hasDbXref
- Wikipedia:Pemetrexed
- DRON_00010000
- 68446
- oboInOwl#id
- CHEBI:63616
- generic_name
- Pemetrexed Disodium Amorphous
- brand_name
- Pemfexy
- brand_name_base
- Pemfexy
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_63721
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#is_conjugate_acid_of
- http://purl.obolibrary.org/obo/CHEBI_63724
- core#notation
- CHEBI:63616
- pharm_class_epc
- Folate Analog Metabolic Inhibitor [EPC]
- pharm_class
- Folic Acid Metabolism Inhibitors [MoA]
- pharm_class_moa
- Folic Acid Metabolism Inhibitors [MoA]
- upc
- 0363323622008
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- package_marketing_start_date
- 26-MAR-14
- manufacturer_name
- Shilpa Medicare Limited
- rxcui
- 1728079
- active_ingredient_name
- PEMETREXED MONOHYDRATE
- active_ingredient_strength
- 100 mg/4.2mL
- unii
- 236Y2F7D9J
- spl_set_id
- 8b660f68-b770-4e0a-b2f9-25e663deecc3
- nui
- N0000000111
- has_treatment
- http://purl.obolibrary.org/obo/DOID_6201
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect30603
- chebi#is_conjugate_base_of
- http://purl.obolibrary.org/obo/CHEBI_63724
- owl#annotatedSource
- t262953
- owl#someValuesFrom
- t3006550