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Pergolide

CHEBI:CHEBI_63617

Definition

A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.

Chemical Information

Molecular Formula
C19H26N2S
Molecular Mass
314.48800
Charge
0
SMILES
[H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CSC)CN2CCC
InChI
InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1
InChIKey
YEHCICAEULNIGD-MZMPZRCHSA-N

Alternative Names

  • (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline
  • pergolida
  • pergolide
  • pergolidum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
8047
oboInOwl#hasDbXref
Wikipedia:Pergolide
core#notation
CHEBI:63617

Additional References

Wikipedia:Pergolide

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
8047
oboInOwl#hasDbXref
Wikipedia:Pergolide
oboInOwl#id
CHEBI:63617
core#notation
CHEBI:63617
oboInOwl#hasAlternativeId
CHEBI:8020
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_51065
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_63706
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_111819
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_63706
owl#annotatedSource
t262834
owl#someValuesFrom
t836056