Vemurafenib
CHEBI:CHEBI_63637
Definition
A pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone formal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases.
Chemical Information
- Molecular Formula
- C23H18ClF2N3O3S
- Molecular Mass
- 489.920
- Charge
- 0
- SMILES
- CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=CNC3=C2C=C(C=N3)C2=CC=C(Cl)C=C2)=C1F
- InChI
- InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
- InChIKey
- GPXBXXGIAQBQNI-UHFFFAOYSA-N
Alternative Names
- N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide
- PLX 4032
- PLX-4032
- PLX4032
- RG 7204
- RG-7204
- RG7204
- Ro 51-85426
- RO 5185426
- RO-51-85426
- RO-5185426
- RO5185426
- vemurafenib
- vemurafenibum
- Zelboraf
Drug Classification
-
sulfonamideView Class →
CHEBI:35358
-
difluorobenzeneView Class →
CHEBI:38582
-
monochlorobenzenesView Class →
CHEBI:83403
-
pyrrolopyridineView Class →
CHEBI:46771
-
aromatic ketoneView Class →
CHEBI:76224
-
t262379
-
t262783
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- core#notation
- CHEBI:63637
- DRON_00010000
- 1147220
- oboInOwl#hasDbXref
- Wikipedia:Vemurafenib
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- core#notation
- CHEBI:63637
- pharm_class
- Protein Kinase Inhibitors [MoA]
- pharm_class_moa
- P-Glycoprotein Inhibitors [MoA]
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1147220
- oboInOwl#hasDbXref
- Wikipedia:Vemurafenib
- oboInOwl#hasAlternativeId
- CHEBI:194457
- oboInOwl#id
- CHEBI:63637
- generic_name
- Vemurafenib
- rxcui
- 1147228
- product_type
- HUMAN PRESCRIPTION DRUG
- marketing_category
- NDA
- listing_expiration_date
- 20251231
- route
- ORAL
- dosage_form
- TABLET, FILM COATED
- nui
- N0000182138
- active_ingredient_strength
- 240 mg/1
- pharm_class_epc
- Kinase Inhibitor [EPC]
- labeler_name
- Genentech, Inc.
- manufacturer_name
- Genentech, Inc.
- package_marketing_start_date
- 20150908
- marketing_start_date
- 20110817
- brand_name
- ZELBORAF
- brand_name_base
- ZELBORAF
- product_ndc
- 50242-090
- application_number
- NDA202429
- spl_id
- 2c9b0bf4-31be-452a-83a8-d62c0c691a48
- active_ingredient_name
- VEMURAFENIB
- package_ndc
- 50242-090-02
- package_description
- 1 BOTTLE, PLASTIC in 1 CARTON (50242-090-02) / 112 TABLET, FILM COATED in 1 BOTTLE, PLASTIC
- unii
- 207SMY3FQT
- spl_set_id
- 38eea320-7e0c-485a-bc30-98c3c45e2763
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_75047
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- has_treatment
- http://purl.obolibrary.org/obo/DOID_5233
- owl#annotatedSource
- t262896
- owl#someValuesFrom
- t1092894