Discuss This Drug

tenofovir disoproxil

CHEBI:CHEBI_63717

Definition

An organic phosphonate that is the disoproxil ester of tenofovir. A prodrug for tenofovir, an HIV-1 reverse transcriptase inhibitor, tenofovir disoproxil is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.

Chemical Information

Molecular Formula
C19H30N5O10P
Molecular Mass
519.44280
Charge
0
SMILES
CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C
InChI
InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1
InChIKey
JFVZFKDSXNQEJW-CQSZACIVSA-N

Alternative Names

  • 9-((R)-2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine
  • bis({[(propan-2-yloxy)carbonyl]oxy}methyl) ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonate
  • bis(POC)PMPA
  • PMPA prodrug
  • tenofovir bis(isopropyloxycarbonyloxymethyl) ester

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Reaxys:9018187
DRON_00010000
300195
core#notation
CHEBI:63717

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Reaxys:9018187
DRON_00010000
300195
oboInOwl#id
CHEBI:63717
core#notation
CHEBI:63717
listing_expiration_date
20241231
dosage_form
POWDER
active_ingredient_name
TENOFOVIR DISOPROXIL FUMARATE
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
active_ingredient_strength
1 kg/kg
labeler_name
Hetero Labs Limited
marketing_start_date
20011026
package_marketing_start_date
26-OCT-01
generic_name
Tenofovir Disoproxil
product_ndc
68554-0046
spl_id
f33782f6-0b71-8ebd-e053-2995a90a8a6f
package_ndc
68554-0046-2
package_description
50 kg in 1 DRUM (68554-0046-2)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50266
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_63625
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_2237
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect30835
owl#annotatedSource
t266350
owl#someValuesFrom
t3273621