Discuss This Drug

leflunomide

CHEBI:CHEBI_6402

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Chemical Information

Molecular Formula
C12H9F3N2O2
Molecular Mass
270.20730
Charge
0
SMILES
Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F
InChI
InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
InChIKey
VHOGYURTWQBHIL-UHFFFAOYSA-N

Alternative Names

  • 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
  • 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
  • alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide
  • Arava
  • leflunomida
  • leflunomide
  • Leflunomide
  • leflunomidum
  • 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
27169
oboInOwl#hasDbXref
Wikipedia:Leflunomide
core#notation
CHEBI:6402

Additional References

Wikipedia:Leflunomide

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
route
ORAL
marketing_start_date
20190613
spl_id
3612d39b-c21d-467b-995b-59ed64082962
package_ndc
72162-2409-3
labeler_name
sanofi-aventis U.S. LLC
package_marketing_start_date
19980919
package_description
30 TABLET in 1 BOTTLE (72162-2409-3)
has_treatment
http://purl.obolibrary.org/obo/DOID_2980
Medication
http://purl.obolibrary.org/obo/DOID_0040086
owl#annotatedSource
t266266
owl#someValuesFrom
t726019
oboInOwl#hasOBONamespace
chebi_ontology
brand_name
LEFLUNOMIDE
brand_name_base
LEFLUNOMIDE
oboInOwl#id
CHEBI:6402
generic_name
LEFLUNOMIDE
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
POWDER
product_ndc
72162-2409
application_number
ANDA212453
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
DRON_00010000
27169
oboInOwl#hasDbXref
Wikipedia:Leflunomide
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_68543
core#notation
CHEBI:6402
rxcui
213380
active_ingredient_strength
24 kg/24kg
manufacturer_name
KVK-Tech, Inc.
pharm_class_epc
Antirheumatic Agent [EPC]
pharm_class
Antirheumatic Agent [EPC]
active_ingredient_name
LEFLUNOMIDE
unii
G162GK9U4W
spl_set_id
e76d7767-744f-4e52-956d-e59f7a924826
nui
N0000175713
upc
0323155043037
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect30950