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Benserazide

CHEBI:CHEBI_64187

Definition

A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.

Chemical Information

Molecular Formula
C10H15N3O5
Molecular Mass
257.24320
Charge
0
SMILES
NC(CO)C(=O)NNCc1ccc(O)c(O)c1O
InChI
InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18)
InChIKey
BNQDCRGUHNALGH-UHFFFAOYSA-N

Alternative Names

  • 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide
  • benserazida
  • benserazide
  • benserazidum
  • DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazide
  • DL-serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide
  • Ro 4-4602
  • Ro 44602

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1374
oboInOwl#hasDbXref
Wikipedia:Benserazide
core#notation
CHEBI:64187

Additional References

Wikipedia:Benserazide

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Additional Attributes

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