crizotinib
CHEBI:CHEBI_64310
Definition
A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
Chemical Information
- Molecular Formula
- C21H22Cl2FN5O
- Molecular Mass
- 450.33700
- Charge
- 0
- SMILES
- C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
- InChI
- InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
- InChIKey
- KTEIFNKAUNYNJU-GFCCVEGCSA-N
Alternative Names
- (R)-crizotinib
- 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
- crizotinib
- crizotinibum
- PF 2341066
- PF-2341066
Drug Classification
-
t265652
-
t265681
-
t265688
-
t266174
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- core#notation
- CHEBI:64310
- DRON_00010000
- 1148495
- oboInOwl#hasDbXref
- Wikipedia:Crizotinib
Additional References
Wikipedia:Crizotinib
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- core#notation
- CHEBI:64310
- rxcui
- 2670178
- nui
- N0000191265
- pharm_class_moa
- Organic Cation Transporter 1 Inhibitors [MoA]
- pharm_class
- Organic Cation Transporter 1 Inhibitors [MoA]
- active_ingredient_strength
- 1 kg/kg
- pharm_class_epc
- Kinase Inhibitor [EPC]
- manufacturer_name
- Pfizer Laboratories Div Pfizer Inc
- package_marketing_start_date
- 26-MAR-23
- active_ingredient_name
- CRIZOTINIB
- package_description
- 60 CAPSULE in 1 BOTTLE (0069-8141-20)
- unii
- 53AH36668S
- spl_set_id
- 2a51b0de-47d6-455e-a94c-d2c737b04ff7
- upc
- 0300698141208
- package_ndc
- 0069-0251-60
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1148495
- oboInOwl#hasDbXref
- Wikipedia:Crizotinib
- oboInOwl#id
- CHEBI:64310
- oboInOwl#hasAlternativeId
- CHEBI:77554
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT
- listing_expiration_date
- 20241231
- route
- ORAL
- dosage_form
- CAPSULE, COATED PELLETS
- marketing_start_date
- 20230326
- labeler_name
- Pfizer Asia Manufacturing Pte Ltd
- generic_name
- Crizotinib
- product_ndc
- 0069-8141
- spl_id
- 0d678cf0-e318-ca3e-e063-6394a90abc7c
- brand_name
- Xalkori
- brand_name_base
- Xalkori
- application_number
- NDA202570
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_59163
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#is_enantiomer_of
- http://purl.obolibrary.org/obo/CHEBI_77555
- has_treatment
- http://purl.obolibrary.org/obo/DOID_4832
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect31036
- owl#annotatedSource
- t266406
- owl#someValuesFrom
- t1092409