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Fosaprepitant dimeglumine

CHEBI:CHEBI_64311

Definition

An organoammonium salt obtained by reaction of fosaprepitant with two equivalents of 1-deoxy-1-(methylamino)-D-glucitol. A substance P/neurokinin 1 (NK1) receptor antagonist. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting and postoperative nausea and vomiting

Chemical Information

Molecular Formula
C37H56F7N6O16P
Molecular Mass
1004.83370
Charge
0
SMILES
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C[C@@H](O[C@H]1OCCN(Cc2nn(c(=O)[nH]2)P(O)(O)=O)[C@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
InChI
InChI=1S/C23H22F7N4O6P.2C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;2*1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);2*4-13H,2-3H2,1H3/t12-,19+,20-;2*4-,5+,6+,7+/m100/s1
InChIKey
VRQHBYGYXDWZDL-OOZCZQCLSA-N

Alternative Names

  • (3-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid--1-deoxy-1-(methylamino)-D-glucitol (1/2)
  • bis[1-deoxy-1-(methylazaniumyl)-D-glucitol] (3-{[(2R,3S)-2-{(1R,)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate
  • Fosaprepitant meglumine
  • MK-0517

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:64311
DRON_00010000
754763
oboInOwl#hasDbXref
Reaxys:8608007

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:64311
rxcui
1731077
pharm_class
Neurokinin 1 Antagonists [MoA]
package_marketing_start_date
25-JAN-08
manufacturer_name
BluePoint Laboratories
active_ingredient_strength
150 mg/50mL
active_ingredient_name
FOSAPREPITANT DIMEGLUMINE
package_description
640 VIAL, GLASS in 1 CASE (63552-011-01) / 10 mL in 1 VIAL, GLASS
unii
D35FM8T64X
spl_set_id
3ed3e0a9-a0a8-4555-9f73-2043e79e3398
upc
0368001523363
package_ndc
0338-0008-01
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
754763
oboInOwl#hasDbXref
Reaxys:8608007
oboInOwl#id
CHEBI:64311
generic_name
FOSAPREPITANT DIMEGLUMINE
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
route
INTRAVENOUS
marketing_start_date
20080125
labeler_name
BluePoint Laboratories
product_ndc
63552-011
spl_id
10ae0f23-6360-47ab-a43c-3a5a01d3b029
brand_name
FOCINVEZ
brand_name_base
FOCINVEZ
application_number
ANDA211860
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_55350
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_64322
owl#annotatedSource
t266361
owl#someValuesFrom
t633075