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fosaprepitant

CHEBI:CHEBI_64321

Definition

A morpholine derivative that is the (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl ether of (3-{[(2R,3S)-3-(4-fluorophenyl)-2-hydroxymorpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid.

Chemical Information

Molecular Formula
C23H22F7N4O6P
Molecular Mass
614.40660
Charge
0
SMILES
C[C@@H](O[C@H]1OCCN(Cc2nn(c(=O)[nH]2)P(O)(O)=O)[C@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
InChI
InChI=1S/C23H22F7N4O6P/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38)/t12-,19+,20-/m1/s1
InChIKey
BARDROPHSZEBKC-OITMNORJSA-N

Alternative Names

  • (3-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
  • fosaprepitant
  • fosaprepitantum
  • L-758,298
  • L-758298

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:64321
DRON_00010000
1731071
oboInOwl#hasDbXref
Wikipedia:Fosaprepitant_dimeglumine

Additional References

Wikipedia:Fosaprepitant_dimeglumine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

rxcui
2664071
manufacturer_name
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
package_marketing_start_date
20230128
package_description
1 VIAL, SINGLE-DOSE in 1 CARTON (72205-083-01) / 5 mL in 1 VIAL, SINGLE-DOSE
package_ndc
70121-2631-1
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect31056
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_64322
owl#annotatedSource
t266348
owl#someValuesFrom
t2910448
core#notation
CHEBI:64321
pharm_class
Neurokinin 1 Antagonists [MoA]
active_ingredient_strength
150 mg/50mL
active_ingredient_name
FOSAPREPITANT DIMEGLUMINE
unii
D35FM8T64X
spl_set_id
a7343abe-b2b0-4e5a-907b-532a8e16dfcb
upc
0372205083011
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1731071
oboInOwl#hasDbXref
Wikipedia:Fosaprepitant_dimeglumine
oboInOwl#id
CHEBI:64321
generic_name
FOSAPREPITANT
brand_name
FOSAPREPITANT
brand_name_base
FOSAPREPITANT
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
product_ndc
72205-083
application_number
ANDA203939
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_55350
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_64322
listing_expiration_date
20241231
labeler_name
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
route
INTRAVENOUS
marketing_start_date
20230128
spl_id
a7343abe-b2b0-4e5a-907b-532a8e16dfcb