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Metolazone

CHEBI:CHEBI_64354

Definition

A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.

Chemical Information

Molecular Formula
C16H16ClN3O3S
Molecular Mass
365.83500
Charge
0
SMILES
CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O
InChI
InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
InChIKey
AQCHWTWZEMGIFD-UHFFFAOYSA-N

Alternative Names

  • 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
  • 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
  • 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide
  • 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
  • metolazona
  • metolazone
  • metolazonum
  • Zaroxolyn

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
6916
oboInOwl#hasDbXref
Wikipedia:Metolazone
core#notation
CHEBI:64354

Additional References

Wikipedia:Metolazone

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

route
ORAL
package_ndc
0378-6174-01
package_description
100 TABLET in 1 BOTTLE, PLASTIC (0378-6174-01)
spl_id
0c3a7f55-1ceb-e6bf-e063-6294a90afccb
package_marketing_start_date
27-NOV-73
manufacturer_name
Aarkish Pharmaceuticals NJ Inc.
product_type
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
POWDER
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
marketing_start_date
20041019
labeler_name
Aarkish Pharmaceuticals NJ Inc.
application_number
ANDA216216
product_ndc
0185-0055
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
6916
oboInOwl#hasDbXref
Wikipedia:Metolazone
oboInOwl#id
CHEBI:64354
oboInOwl#hasAlternativeId
CHEBI:6903
generic_name
METOLAZONE
brand_name
METOLAZONE
brand_name_base
METOLAZONE
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50184
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00000059
core#notation
CHEBI:64354
rxcui
311671
nui
N0000175420
pharm_class_pe
Increased Diuresis [PE]
pharm_class
Thiazide-like Diuretic [EPC]
active_ingredient_strength
50 kg/50kg
pharm_class_epc
Thiazide-like Diuretic [EPC]
active_ingredient_name
METOLAZONE
unii
TZ7V40X7VX
spl_set_id
c9e51766-8f1d-4258-9f40-1d394e2de04c
upc
0381005126019
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_2527
owl#annotatedSource
t266444
owl#someValuesFrom
t897878