Discuss This Drug

carfilzomib

CHEBI:CHEBI_65347

Definition

A synthetic tetrapeptide consisting of morpholin-4-acetyl, L-2-amino-4-phenylbutanoyl, L-leucyl and L-phenylalanyl residues joined in sequence with the C-terminus connected to the amino group of (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-1-one via an amide linkage. Used for the treatment of patients with multiple myeloma

Chemical Information

Molecular Formula
C40H57N5O7
Molecular Mass
719.911
Charge
0
SMILES
C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C([C@@]1(OC1)C)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)CCC3=CC=CC=C3)=O)N4CCOCC4
InChI
InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1
InChIKey
BLMPQMFVWMYDKT-NZTKNTHTSA-N

Alternative Names

  • carfilzomib
  • Kyprolis
  • N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1302966
oboInOwl#hasDbXref
Wikipedia:Carfilzomib
core#notation
CHEBI:65347

Additional References

Wikipedia:Carfilzomib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1302966
generic_name
Carfilzomib
oboInOwl#hasDbXref
Wikipedia:Carfilzomib
oboInOwl#id
CHEBI:65347
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
POWDER, FOR SOLUTION
marketing_start_date
20121016
brand_name
KYPROLIS
brand_name_base
KYPROLIS
product_ndc
52076-6251
application_number
NDA202714
labeler_name
Chunghwa Chemical Synthesis & Biotech. Ltd
spl_id
0aebaff5-8491-4bc3-94d4-2d5d1c309eeb
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_52726
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:65347
rxcui
2046644
route
INTRAVENOUS
package_marketing_start_date
20-JUL-12
active_ingredient_strength
30 mg/15mL
nui
N0000175075
pharm_class_epc
Proteasome Inhibitor [EPC]
pharm_class
Proteasome Inhibitors [MoA]
pharm_class_moa
Proteasome Inhibitors [MoA]
manufacturer_name
Onyx Pharmaceuticals, Inc.
active_ingredient_name
CARFILZOMIB
package_ndc
52076-6251-3
package_description
50 kg in 1 DRUM (52076-6251-3)
unii
72X6E3J5AR
spl_set_id
ea66eb30-e665-4693-99a1-a9d3b4bbe2d6
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_105268
has_treatment
http://purl.obolibrary.org/obo/DOID_0080937
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect31357
owl#annotatedSource
t269821
owl#someValuesFrom
t3046637