ivacaftor
CHEBI:CHEBI_66901
Definition
An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis.
Chemical Information
- Molecular Formula
- C24H28N2O3
- Molecular Mass
- 392.49070
- Charge
- 0
- SMILES
- CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C
- InChI
- InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)
- InChIKey
- PURKAOJPTOLRMP-UHFFFAOYSA-N
Alternative Names
- ivacaftor
- ivacaftorum
- Kalydeco
- N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
- VX-770
Drug Classification
-
quinoloneView Class →
CHEBI:23765
-
monocarboxylic acid amideView Class →
CHEBI:29347
-
phenolsView Class →
CHEBI:33853
-
aromatic amideView Class →
CHEBI:62733
-
t268700
-
t269758
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- core#notation
- CHEBI:66901
- DRON_00010000
- 1243041
- oboInOwl#hasDbXref
- Wikipedia:Ivacaftor
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- core#notation
- CHEBI:66901
- pharm_class_moa
- Chloride Channel Activation Potentiators [MoA]
- pharm_class
- Chloride Channel Activation Potentiators [MoA]
- nui
- N0000190114
- pharm_class_epc
- Cystic Fibrosis Transmembrane Conductance Regulator Potentiator [EPC]
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rxcui
- 2636793
- listing_expiration_date
- 20241231
- route
- ORAL
- active_ingredient_strength
- 7.5 kg/7.5kg
- package_marketing_start_date
- 05-MAR-24
- spl_id
- 7dd28ef5-c72e-4035-a1b1-fd2e0be98cff
- active_ingredient_name
- IVACAFTOR
- package_ndc
- 65129-1450-0
- package_description
- 7.5 kg in 1 DRUM (65129-1450-0)
- manufacturer_name
- Vertex Pharmaceuticals Incorporated
- unii
- 1Y740ILL1Z
- spl_set_id
- 0ab0c9f8-3eee-4e0f-9f3f-c1e16aaffe25
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1243041
- oboInOwl#hasDbXref
- Wikipedia:Ivacaftor
- oboInOwl#id
- CHEBI:66901
- generic_name
- Ivacaftor spary dried dispersion
- brand_name
- Kalydeco
- brand_name_base
- Kalydeco
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
- dosage_form
- GRANULE
- marketing_start_date
- 20210208
- labeler_name
- HOVIONE LIMITED
- product_ndc
- 65129-1450
- application_number
- NDA203188
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_71031
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- has_treatment
- http://purl.obolibrary.org/obo/DOID_0050739
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect31528
- owl#annotatedSource
- t269675
- owl#someValuesFrom
- t3969831