Discuss This Drug

vismodegib

CHEBI:CHEBI_66903

Definition

A benzamide obtained by formal condensation between the carboxy group of 2-chloro-4-(methylsulfonyl)benzoic acid and the anilino group of 4-chloro-3-(pyridin-2-yl)aniline. Used for the treatment metastatic basal cell carcinoma.

Chemical Information

Molecular Formula
C19H14Cl2N2O3S
Molecular Mass
421.29700
Charge
0
SMILES
CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(c2)-c2ccccn2)c(Cl)c1
InChI
InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
InChIKey
BPQMGSKTAYIVFO-UHFFFAOYSA-N

Alternative Names

  • 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide
  • Erivedge
  • vismodegib
  • vismodegibum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1242987
oboInOwl#hasDbXref
Wikipedia:Vismodegib
core#notation
CHEBI:66903

Additional References

Wikipedia:Vismodegib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1242987
oboInOwl#hasDbXref
Wikipedia:Vismodegib
oboInOwl#id
CHEBI:66903
core#notation
CHEBI:66903
generic_name
vismodegib
rxcui
1242998
product_type
HUMAN PRESCRIPTION DRUG
marketing_category
NDA
route
ORAL
listing_expiration_date
20241231
dosage_form
CAPSULE
active_ingredient_strength
150 mg/1
nui
N0000184148
pharm_class_epc
Hedgehog Pathway Inhibitor [EPC]
pharm_class
Smoothened Receptor Antagonists [MoA]
pharm_class_moa
Smoothened Receptor Antagonists [MoA]
labeler_name
Genentech, Inc.
manufacturer_name
Genentech, Inc.
marketing_start_date
20120130
package_marketing_start_date
20130409
brand_name
ERIVEDGE
brand_name_base
ERIVEDGE
product_ndc
50242-140
application_number
NDA203388
spl_id
e0e041f9-94d4-4ec0-8aa5-f6b06e5b6320
active_ingredient_name
VISMODEGIB
package_ndc
50242-140-86
package_description
1 BOTTLE, PLASTIC in 1 CARTON (50242-140-86) / 28 CAPSULE in 1 BOTTLE, PLASTIC
unii
25X868M3DS
spl_set_id
eb368bb6-80e3-4df9-8a85-91df0a2ada6a
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_66908
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http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_6609
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_112746
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https://w3id.org/def/predibionto#has_side_effect31534
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t269884
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t1102112