Discuss This Drug

clofarabine

CHEBI:CHEBI_681569

Definition

A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia.

Chemical Information

Molecular Formula
C10H11ClFN5O3
Molecular Mass
303.67700
Charge
0
SMILES
Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F
InChI
InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
InChIKey
WDDPHFBMKLOVOX-AYQXTPAHSA-N

Alternative Names

  • (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
  • 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
  • 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
  • 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine
  • CAFdA
  • Cl-F-Ara-A
  • clofarabina
  • clofarabine
  • clofarabine
  • clofarabinum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
44151
oboInOwl#hasDbXref
Wikipedia:Clofarabine
core#notation
CHEBI:681569

Additional References

Wikipedia:Clofarabine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
44151
oboInOwl#hasDbXref
Wikipedia:Clofarabine
oboInOwl#id
CHEBI:681569
generic_name
CLOFARABINE
brand_name
Clolar
brand_name_base
Clolar
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
INJECTION
marketing_start_date
20181114
labeler_name
Amneal Pharmaceuticals LLC
product_ndc
68083-386
application_number
NDA021673
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35610
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
rxcui
544915
listing_expiration_date
20241231
route
INTRAVENOUS
package_marketing_start_date
24-JAN-14
active_ingredient_strength
1 kg/kg
manufacturer_name
Amneal Pharmaceuticals LLC
nui
N0000175595
spl_id
e35a63ca-af60-4142-a5af-37640734e820
active_ingredient_name
CLOFARABINE
package_ndc
68083-386-01
package_description
1 VIAL, SINGLE-DOSE in 1 CARTON (68083-386-01) / 20 mL in 1 VIAL, SINGLE-DOSE
unii
762RDY0Y2H
spl_set_id
b7d3a96e-0280-4f14-b921-795996f75950
upc
0368083386016
core#notation
CHEBI:681569
pharm_class_moa
Nucleic Acid Synthesis Inhibitors [MoA]
pharm_class
Nucleoside Metabolic Inhibitor [EPC]
pharm_class_epc
Nucleoside Metabolic Inhibitor [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_3405
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect32028
owl#annotatedSource
t273139
owl#someValuesFrom
t3056251