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Doxapram

CHEBI:CHEBI_681848

Definition

A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.

Chemical Information

Molecular Formula
C24H30N2O2
Molecular Mass
378.50720
Charge
0
SMILES
CCN1CC(CCN2CCOCC2)C(C1=O)(c1ccccc1)c1ccccc1
InChI
InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3
InChIKey
XFDJYSQDBULQSI-UHFFFAOYSA-N

Alternative Names

  • (+-)-doxapram
  • 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone
  • 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one
  • doxapram
  • Doxapram

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
3637
oboInOwl#hasDbXref
Wikipedia:Doxapram
core#notation
CHEBI:681848

Additional References

Wikipedia:Doxapram

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
3637
oboInOwl#hasDbXref
Wikipedia:Doxapram
oboInOwl#id
CHEBI:681848
core#notation
CHEBI:681848
rxcui
1047087
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
INJECTION
route
INTRAVENOUS
active_ingredient_strength
1 kg/kg
labeler_name
HF Acquisition Co LLC, DBA HealthFirst
manufacturer_name
HF Acquisition Co LLC, DBA HealthFirst
marketing_start_date
20191019
package_marketing_start_date
25-OCT-17
generic_name
Doxapram hydrochloride monohydrate
brand_name
DOXAPRAM HYDROCHLORIDE
brand_name_base
DOXAPRAM HYDROCHLORIDE
active_ingredient_name
DOXAPRAM HYDROCHLORIDE
product_ndc
10920-601
application_number
NDA014879
spl_id
b943b27b-2dcc-2ebb-e053-2995a90ab25f
package_ndc
10920-601-02
package_description
5 kg in 1 PACKAGE (10920-601-02)
unii
P5RU6UOQ5Y
spl_set_id
954859c0-a121-34d6-e053-2a95a90a1e19
pharm_class
Respiratory Stimulant [EPC]
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35337
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https://w3id.org/def/predibionto#has_side_effect32059
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t273359
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t484523