Discuss This Drug

everolimus

CHEBI:CHEBI_68478

Definition

A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted into the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.

Chemical Information

Molecular Formula
C53H83NO14
Molecular Mass
958.22440
Charge
0
SMILES
[H][C@]1(CC[C@@H](OCCO)[C@@H](C1)OC)C[C@@H](C)[C@]1([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]2([H])CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@@]2([H])C(=O)O1)OC
InChI
InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
InChIKey
HKVAMNSJSFKALM-GKUWKFKPSA-N

Alternative Names

  • 40-O-(2-hydroxyethyl)-rapamycin
  • 42-O-(2-hydroxyethyl)rapamycin
  • Afinitor
  • Afinitor Disperz
  • Certican
  • everolimus
  • Everolimus
  • everolimusum
  • RAD 001
  • RAD001
  • SDZ RAD
  • SDZ-RAD
  • Votubia
  • Xience V
  • Zortress
  • (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-1,18-dihydroxy-12-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
141704
oboInOwl#hasDbXref
Wikipedia:Everolimus
core#notation
CHEBI:68478

Additional References

Wikipedia:Everolimus

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
route
ORAL
marketing_start_date
20100709
spl_id
dfed65a0-1c5a-4897-a33c-373137b7f88d
package_ndc
65129-1324-0
labeler_name
Mylan Pharmaceuticals Inc.
package_marketing_start_date
14-JAN-15
package_description
30 TABLET in 1 BOTTLE (72603-256-01)
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_9168
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
TABLET, FOR SUSPENSION
application_number
ANDA206133
product_ndc
67877-720
rxcui
2685208
active_ingredient_strength
.75 mg/1
nui
N0000175550
manufacturer_name
Biocon Pharma Inc.
active_ingredient_name
EVEROLIMUS
unii
9HW64Q8G6G
spl_set_id
4c0075dd-a0a8-4dc4-be32-1be8383fbbdc
upc
0302450825302
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
141704
brand_name
TORPENZ
brand_name_base
TORPENZ
oboInOwl#hasDbXref
Wikipedia:Everolimus
oboInOwl#id
CHEBI:68478
generic_name
Everolimus B02
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_68481
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:68478
pharm_class_moa
mTOR Inhibitors [MoA]
pharm_class
mTOR Inhibitors [MoA]
pharm_class_epc
mTOR Inhibitor Immunosuppressant [EPC]
pharm_class_pe
Decreased Immunologic Activity [PE]
brand_name_suffix
Disperz
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect32253
owl#annotatedSource
t273376
owl#someValuesFrom
t3103274
has_treatment
http://purl.obolibrary.org/obo/DOID_0070511