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icatibant

CHEBI:CHEBI_68556

Definition

A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acute attacks of hereditary angioedema in adult patients.

Chemical Information

Molecular Formula
C59H89N19O13S
Molecular Mass
1304.526
Charge
0
SMILES
N1(C([C@@H](NC([C@@H](CCCNC(=N)N)N)=O)CCCNC(N)=N)=O)[C@@H](CCC1)C(N2C[C@@H](C[C@H]2C(NCC(N[C@H](C(N[C@H](C(N3CC=4C(C[C@@H]3C(N5[C@@H](C[C@]6([C@@]5(CCCC6)[H])[H])C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=CC=CC4)=O)CO)=O)CC7=CC=CS7)=O)=O)O)=O
InChI
InChI=1S/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+/m0/s1
InChIKey
QURWXBZNHXJZBE-SKXRKSCCSA-N

Alternative Names

  • D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-L-arginine
  • H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
  • icatibant
  • icatibanto
  • icatibantum
  • (2S)-2-({[(2S,3aS,7aS)-1-({(3R)-2-[(2S)-2-{[(2S)-2-[2-({[(2S,4R)-1-({(2S)-1-[(2S)-2-{[(2R)-2-amino-5-carbamimidamidopentanoyl]amino}-5-carbamimidamidopentanoyl]pyrrolidin-2-yl}carbonyl)-4-hydroxypyrrolidin-2-yl]carbonyl}amino)acetamido]-3-(thiophen-2-yl)propanoyl]amino}-3-hydroxypropanoyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}carbonyl)octahydro-1H-indol-2-yl]carbonyl}amino)-5-carbamimidamidopentanoic acid

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:68556
DRON_00010000
1148138
oboInOwl#hasDbXref
Wikipedia:Icatibant

Additional References

Wikipedia:Icatibant

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
marketing_start_date
20140722
package_marketing_start_date
22-JUL-14
spl_id
16ef6bfb-9dd3-f4cb-e063-6394a90a22bf
route
SUBCUTANEOUS
package_ndc
24201-207-03
package_description
3 CARTON in 1 CARTON (24201-207-03) / 1 SYRINGE, GLASS in 1 CARTON / 3 mL in 1 SYRINGE, GLASS
labeler_name
Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
core#notation
CHEBI:68556
rxcui
1148145
manufacturer_name
Eugia US LLC
active_ingredient_name
ICATIBANT ACETATE
active_ingredient_strength
100 kg/100kg
unii
325O8467XK
spl_set_id
94a53361-4eda-4e30-a153-44cd142983dd
pharm_class
Bradykinin B2 Receptor Antagonists [MoA]
upc
0355150351015
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1148138
oboInOwl#hasDbXref
Wikipedia:Icatibant
oboInOwl#id
CHEBI:68556
generic_name
Icatibant acetate
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, SOLUTION
brand_name
ICATIBANT
brand_name_base
ICATIBANT
product_ndc
24201-207
application_number
ANDA211021
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_68557
has_treatment
http://purl.obolibrary.org/obo/DOID_1558
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_103793
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect32396
owl#annotatedSource
t273210
owl#someValuesFrom
t673455