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Rilpivirine

CHEBI:CHEBI_68606

Definition

An aminopyrimidine that is pyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 4-cyanophenyl and 4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl groups respectively. Used for treatment of HIV.

Chemical Information

Molecular Formula
C22H18N6
Molecular Mass
366.41850
Charge
0
SMILES
Cc1cc(\C=C\C#N)cc(C)c1Nc1ccnc(Nc2ccc(cc2)C#N)n1
InChI
InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
InChIKey
YIBOMRUWOWDFLG-ONEGZZNKSA-N

Alternative Names

  • 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
  • 4-{[4-({4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
  • rilpivirine
  • TMC 278
  • TMC278

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Rilpivirine
DRON_00010000
1102270
core#notation
CHEBI:68606

Additional References

Wikipedia:Rilpivirine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
marketing_start_date
20100719
package_marketing_start_date
11-NOV-24
labeler_name
Delmar Chemicals Inc.
spl_id
0bff4ef4-c714-72f3-e063-6394a90ad5a8
package_ndc
50370-0052-1
package_description
60 kg in 1 DRUM (50370-0052-1)
dosage_form
POWDER
application_number
NDA202022
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Rilpivirine
DRON_00010000
1102270
oboInOwl#id
CHEBI:68606
generic_name
rilpivirine hydrochloride
product_ndc
50370-0052
brand_name
EDURANT
brand_name_base
EDURANT
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_53756
oboInOwl#inSubset
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chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_68605
core#notation
CHEBI:68606
rxcui
2678248
active_ingredient_strength
100 kg/100kg
active_ingredient_name
RILPIVIRINE HYDROCHLORIDE
pharm_class
Non-Nucleoside Analog [EXT]
manufacturer_name
Janssen Products, LP
unii
212WAX8KDD
spl_set_id
03880372-2c68-45c6-a53a-f420c49541d6
upc
0359676278016
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owl#annotatedSource
t276802
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t3866572