Linagliptin

CHEBI:CHEBI_68610

Definition

A xanthine that is 7H-xanthine bearing (4-methylquinazolin-2-yl)methyl, methyl, but-2-yn-1-yl and 3-aminopiperidin-1-yl substituents at positions 1, 3, 7 and 8 respectively (the R-enantiomer). Used for treatment of type II diabetes.

Chemical Information

Molecular Formula: C25H28N8O2
Molecular Mass: 472.54220
Charge: 0
SMILES: CC#CCn1c(nc2n(C)c(=O)n(Cc3nc(C)c4ccccc4n3)c(=O)c12)N1CCC[C@@H](N)C1
InChI: InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1
InChIKey: LTXREWYXXSTFRX-QGZVFWFLSA-N

Alternative Names

(R)-8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
BI 1356
linagliptin
Tradjenta
8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione

Treatment Applications

type 1 diabetes mellitus 3
DOID:0110742

View Disease →
type 1 diabetes mellitus 11
DOID:0110750

View Disease →
obsolete diabetes mellitus juvenile type, uncontrolled, with neurological manifestations
DOID:10469

View Disease →

Drug Classification

quinazolines
CHEBI:38530

View Class →
aminopiperidine
CHEBI:48588

View Class →
t276145
t276592
t276826

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

Always consult with a healthcare professional before starting, stopping, or modifying any medication.
Side effects may vary and this list may not be comprehensive.
Drug interactions may occur with other medications.

Additional Identifiers

core#notation: CHEBI:68610
DRON_00010000: 1100699
oboInOwl#hasDbXref: Wikipedia:Linagliptin

Additional References

Wikipedia:Linagliptin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace: chebi_ontology
oboInOwl#id: CHEBI:68610
generic_name: linagliptin and metformin hydrochloride
brand_name: Jentadueto XR
brand_name_base: Jentadueto XR
product_type: BULK INGREDIENT
marketing_category: BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
listing_expiration_date: 20241231
dosage_form: TABLET, FILM COATED, EXTENDED RELEASE
marketing_start_date: 20110509
labeler_name: Cardinal Health 107, LLC
product_ndc: 62993-0808
spl_id: f38efc46-3ca0-73f1-e053-2995a90a1cc4
application_number: NDA201280
oboInOwl#inSubset: http://purl.obolibrary.org/obo/chebi#3_STAR
route: ORAL
package_ndc: 62993-0808-1
package_description: 1 kg in 1 DRUM (62993-0808-1)
core#notation: CHEBI:68610
rxcui: 1796096
active_ingredient_strength: 850 mg/1
active_ingredient_name: LINAGLIPTIN
unii: 3X29ZEJ4R2
pharm_class: Dipeptidyl Peptidase 4 Inhibitors [MoA]
manufacturer_name: Cardinal Health 107, LLC
nui: N0000175913
pharm_class_epc: Dipeptidyl Peptidase 4 Inhibitor [EPC]
pharm_class_moa: Dipeptidyl Peptidase 4 Inhibitors [MoA]
package_marketing_start_date: 30-JAN-15
spl_set_id: b1da67d4-51e0-41b7-9fe1-7f38c0d1baa1
upc: 0355154041080
22-rdf-syntax-ns#type: http://www.w3.org/2002/07/owl#Class
DRON_00010000: 1100699
oboInOwl#hasDbXref: Wikipedia:Linagliptin
RO_0000087: http://purl.obolibrary.org/obo/CHEBI_68612
chebi#has_functional_parent: http://purl.obolibrary.org/obo/CHEBI_48517
has_treatment: http://purl.obolibrary.org/obo/DOID_0050778
rdf-schema#range: https://w3id.org/def/predibionto#has_drug_107118
owl#annotatedSource: t276758
owl#someValuesFrom: t3511046