Discuss This Drug

regorafenib

CHEBI:CHEBI_68647

Definition

A pyridinecarboxamide obtained by condensation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]pyridine-2-carboxylic acid with methylamine. Used for for the treatment of metastatic colorectal cancer in patients who have previously received chemotherapy, anti-EGFR or anti-VEGF therapy.

Chemical Information

Molecular Formula
C21H15ClF4N4O3
Molecular Mass
482.816
Charge
0
SMILES
C1(=C(C=C(C=C1)NC(NC2=CC=C(C=C2F)OC3=CC=NC(=C3)C(NC)=O)=O)C(F)(F)F)Cl
InChI
InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
InChIKey
FNHKPVJBJVTLMP-UHFFFAOYSA-N

Alternative Names

  • 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
  • BAY 73-4506
  • regorafenib
  • regorafenibum
  • Regorafenibum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:68647
DRON_00010000
1312397
oboInOwl#hasDbXref
Wikipedia:Regorafenib

Additional References

Wikipedia:Regorafenib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:68647
rxcui
1312408
active_ingredient_strength
100 kg/100kg
pharm_class
Kinase Inhibitors [MoA]
package_marketing_start_date
28-AUG-15
manufacturer_name
Bayer HealthCare Pharmaceuticals Inc.
active_ingredient_name
REGORAFENIB MONOHYDRATE
unii
MGN125FS9D
spl_set_id
824f19c9-0546-4a8a-8d8f-c4055c04f7c7
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1312397
oboInOwl#hasDbXref
Wikipedia:Regorafenib
oboInOwl#id
CHEBI:68647
generic_name
Regorafenib Monohydrate
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
POWDER
marketing_start_date
20220329
labeler_name
Bayer HealthCare Pharmaceuticals Inc.
product_ndc
12527-0171
spl_id
a1a84704-d635-48b6-a46a-9e2228001a2e
package_ndc
12527-0171-9
package_description
63559 TABLET, FILM COATED in 1 DRUM (12527-0171-9)
brand_name
Stivarga
brand_name_base
Stivarga
application_number
NDA203085
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50908
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_6268
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect32680
owl#annotatedSource
t276591
owl#someValuesFrom
t1123969