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Midodrine

CHEBI:CHEBI_6933

Definition

An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Chemical Information

Molecular Formula
C12H18N2O4
Molecular Mass
254.28230
Charge
0
SMILES
COc1ccc(OC)c(c1)C(O)CNC(=O)CN
InChI
InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)
InChIKey
PTKSEFOSCHHMPD-UHFFFAOYSA-N

Alternative Names

  • (+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide
  • 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol
  • 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide
  • DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid
  • midodrina
  • midodrine
  • midodrinum
  • rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
6963
oboInOwl#hasDbXref
Wikipedia:Midodrine
core#notation
CHEBI:6933

Additional References

Wikipedia:Midodrine

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Additional Attributes

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chebi_ontology
DRON_00010000
6963
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RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35569
BFO_0000053
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chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_73248
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_73243
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http://www.w3.org/2002/07/owl#Class
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http://purl.obolibrary.org/obo/DOID_4675
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t276823
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t1050092