Discuss This Drug

Midodrine

CHEBI:CHEBI_6933

Definition

An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Chemical Information

Molecular Formula
C12H18N2O4
Molecular Mass
254.28230
Charge
0
SMILES
COc1ccc(OC)c(c1)C(O)CNC(=O)CN
InChI
InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)
InChIKey
PTKSEFOSCHHMPD-UHFFFAOYSA-N

Alternative Names

  • (+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide
  • 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol
  • 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide
  • DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid
  • midodrina
  • midodrine
  • midodrinum
  • rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:6933
DRON_00010000
6963
oboInOwl#hasDbXref
Wikipedia:Midodrine

Additional References

Wikipedia:Midodrine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

rxcui
993470
manufacturer_name
Upsher-Smith laboratories, LLC
package_marketing_start_date
10-SEP-05
unii
59JV96YTXV
spl_set_id
17b24a0b-03e4-4b58-87ab-3d66fec30226
package_description
90 TABLET in 1 BOTTLE, PLASTIC (51407-389-90)
product_type
BULK INGREDIENT
dosage_form
POWDER
marketing_category
BULK INGREDIENT
labeler_name
Edmond Pharma S.R.L
marketing_start_date
20050910
application_number
ANDA207169
product_ndc
0615-8384
listing_expiration_date
20241231
route
ORAL
spl_id
11b96136-761b-d9a9-e063-6294a90a0b1e
package_ndc
63190-0720-5
core#notation
CHEBI:6933
active_ingredient_strength
15 kg/15kg
active_ingredient_name
MIDODRINE HYDROCHLORIDE
pharm_class
alpha-Adrenergic Agonist [EPC]
upc
0370985006015
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
6963
oboInOwl#hasDbXref
Wikipedia:Midodrine
oboInOwl#id
CHEBI:6933
generic_name
Midodrine hydrochloride
brand_name
Midodrine HCl
brand_name_base
Midodrine HCl
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35569
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00723854
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_73248
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_73243
has_treatment
http://purl.obolibrary.org/obo/DOID_4675
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_73243
owl#annotatedSource
t276823
owl#someValuesFrom
t1050092