Discuss This Drug

tofacitinib

CHEBI:CHEBI_71200

Definition

A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.

Chemical Information

Molecular Formula
C16H20N6O
Molecular Mass
312.36960
Charge
0
SMILES
C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N
InChI
InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
InChIKey
UJLAWZDWDVHWOW-YPMHNXCESA-N

Alternative Names

  • 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile
  • CP 690550
  • CP-690550
  • Tasocitinib
  • tofacitinib
  • tofacitinibum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:71200
DRON_00010000
1357536
oboInOwl#hasDbXref
Wikipedia:Tofacitinib

Additional References

Wikipedia:Tofacitinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:71200
rxcui
2478437
active_ingredient_strength
22 mg/1
manufacturer_name
U.S. Pharmaceuticals
active_ingredient_name
TOFACITINIB CITRATE
unii
O1FF4DIV0D
spl_set_id
68e3d6b2-7838-4d2d-a417-09d919b43e13
upc
0300691001011
pharm_class
Janus Kinase Inhibitors [MoA]
brand_name_suffix
XR
package_marketing_start_date
06-NOV-12
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
package_description
1 BAG in 1 DRUM (17337-0085-1) / 1 BAG in 1 BAG / 1 kg in 1 BAG
package_ndc
42571-289-38
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
listing_expiration_date
20241231
route
ORAL
marketing_start_date
20160307
labeler_name
Aurore Pharmaceuticals Private Limited
application_number
NDA208246
spl_id
66feb773-64a1-bc65-e053-2991aa0a7b32
product_type
HUMAN PRESCRIPTION DRUG
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1357536
oboInOwl#hasDbXref
Wikipedia:Tofacitinib
oboInOwl#id
CHEBI:71200
generic_name
Tofacitinib Citrate Micronized
dosage_form
SOLUTION
brand_name
XELJANZ XR
brand_name_base
XELJANZ
product_ndc
17337-0085
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_76617
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_3118
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect33269
owl#annotatedSource
t280280
owl#someValuesFrom
t3745288