Discuss This Drug

Procarbazine

CHEBI:CHEBI_71417

Definition

A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.

Chemical Information

Molecular Formula
C12H19N3O
Molecular Mass
221.29880
Charge
0
SMILES
CNNCc1ccc(cc1)C(=O)NC(C)C
InChI
InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16)
InChIKey
CPTBDICYNRMXFX-UHFFFAOYSA-N

Alternative Names

  • 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine
  • 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine
  • 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide
  • N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide
  • N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
  • N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine
  • N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide
  • N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide
  • N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide
  • p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide
  • Procarbazin
  • procarbazina
  • procarbazine
  • procarbazinum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:71417
DRON_00010000
8702
oboInOwl#hasDbXref
Wikipedia:Procarbazine

Additional References

Wikipedia:Procarbazine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:71417
rxcui
207588
active_ingredient_strength
5 g/5g
pharm_class
Alkylating Drug [EPC]
package_marketing_start_date
05-AUG-23
manufacturer_name
Leadiant Biosciences, Inc.
active_ingredient_name
PROCARBAZINE HYDROCHLORIDE
unii
XH0NPH5ZX8
spl_set_id
1aa75a3a-18c9-49e1-91a6-293d0b7da756
package_description
1 g in 1 PACKAGE (86184-316-01)
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
8702
oboInOwl#hasDbXref
Wikipedia:Procarbazine
oboInOwl#id
CHEBI:71417
oboInOwl#hasAlternativeId
CHEBI:8432
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
CAPSULE
marketing_start_date
20100414
labeler_name
MAEDA INC
generic_name
Procarbazine HCl
brand_name
Matulane
brand_name_base
Matulane
product_ndc
48087-0085
application_number
NDA016785
spl_id
d34b5f58-c0bc-63db-e053-2995a90af474
package_ndc
48087-0085-0
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35610
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_71431
has_treatment
http://purl.obolibrary.org/obo/DOID_6128
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_71431
owl#annotatedSource
t280212
owl#someValuesFrom
t845149