Discuss This Drug

cobicistat

CHEBI:CHEBI_72291

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoic acid with the amino group of 1,3-thiazol-5-ylmethyl [(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate. Acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications..

Chemical Information

Molecular Formula
C40H53N7O5S2
Molecular Mass
776.02300
Charge
0
SMILES
CC(C)c1nc(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1
InChI
InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1
InChIKey
ZCIGNRJZKPOIKD-CQXVEOKZSA-N

Alternative Names

  • 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate
  • cobicistat
  • cobicistatum
  • GS 9350
  • GS-9350

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:72291
DRON_00010000
1306284
oboInOwl#hasDbXref
Wikipedia:Cobicistat

Additional References

Wikipedia:Cobicistat

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:72291
rxcui
1551999
pharm_class_moa
Organic Anion Transporting Polypeptide 1B3 Inhibitors [MoA]
pharm_class
Organic Anion Transporting Polypeptide 1B3 Inhibitors [MoA]
active_ingredient_strength
35 kg/35kg
nui
N0000190108
package_marketing_start_date
27-AUG-12
active_ingredient_name
COBICISTAT
unii
LW2E03M5PG
pharm_class_epc
Cytochrome P450 3A Inhibitor [EPC]
manufacturer_name
Gilead Sciences, Inc.
package_description
100 kg in 1 DRUM (65015-849-61)
spl_set_id
3784c35c-e87f-410c-900b-8fd6313c6010
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1306284
oboInOwl#hasDbXref
Wikipedia:Cobicistat
oboInOwl#id
CHEBI:72291
generic_name
Cobicistat on Silicon Dioxide
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
POWDER
marketing_start_date
20120827
labeler_name
Yuhan Chemical
product_ndc
84206-0024
spl_id
724105da-d6e4-404e-ac01-e048e870f733
package_ndc
84206-0024-1
brand_name
Tybost
brand_name_base
Tybost
application_number
NDA203094
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50183
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect33400
owl#annotatedSource
t280215
owl#someValuesFrom
t3318589