Discuss This Drug

lomitapide

CHEBI:CHEBI_72297

Definition

A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.

Chemical Information

Molecular Formula
C39H37F6N3O2
Molecular Mass
693.722
Charge
0
SMILES
C1(C(NCC(F)(F)F)=O)(CCCCN2CCC(CC2)NC(C3=C(C=CC=C3)C4=CC=C(C=C4)C(F)(F)F)=O)C=5C=CC=CC5C6=C1C=CC=C6
InChI
InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
InChIKey
MBBCVAKAJPKAKM-UHFFFAOYSA-N

Alternative Names

  • AEGR 733
  • AEGR 773
  • AEGR-733
  • AEGR-773
  • AEGR733
  • AEGR773
  • BMS 201038
  • BMS-201038
  • BMS201038
  • Juxtapid
  • Lojuxta
  • lomitapida
  • lomitapide
  • lomitapidum
  • N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1364479
oboInOwl#hasDbXref
Wikipedia:Lomitapide
core#notation
CHEBI:72297

Additional References

Wikipedia:Lomitapide

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1364479
oboInOwl#hasDbXref
Wikipedia:Lomitapide
oboInOwl#id
CHEBI:72297
core#notation
CHEBI:72297
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35821
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_72302
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_13809
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect33471
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_72302
owl#annotatedSource
t280271
owl#someValuesFrom
t2911828