Discuss This Drug

lomitapide

CHEBI:CHEBI_72297

Definition

A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.

Chemical Information

Molecular Formula
C39H37F6N3O2
Molecular Mass
693.722
Charge
0
SMILES
C1(C(NCC(F)(F)F)=O)(CCCCN2CCC(CC2)NC(C3=C(C=CC=C3)C4=CC=C(C=C4)C(F)(F)F)=O)C=5C=CC=CC5C6=C1C=CC=C6
InChI
InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
InChIKey
MBBCVAKAJPKAKM-UHFFFAOYSA-N

Alternative Names

  • AEGR 733
  • AEGR 773
  • AEGR-733
  • AEGR-773
  • AEGR733
  • AEGR773
  • BMS 201038
  • BMS-201038
  • BMS201038
  • Juxtapid
  • Lojuxta
  • lomitapida
  • lomitapide
  • lomitapidum
  • N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:72297
DRON_00010000
1364479
oboInOwl#hasDbXref
Wikipedia:Lomitapide

Additional References

Wikipedia:Lomitapide

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:72297
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1364479
oboInOwl#hasDbXref
Wikipedia:Lomitapide
oboInOwl#id
CHEBI:72297
brand_name
Juxtapid
brand_name_base
Juxtapid
product_type
BULK INGREDIENT
marketing_category
EXPORT ONLY
dosage_form
CAPSULE
labeler_name
Amryt Pharmaceuticals DAC
generic_name
lomitapide mesylate
product_ndc
10122-410
application_number
NDA203858
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35821
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_72302
rxcui
1648772
listing_expiration_date
20241231
route
ORAL
active_ingredient_strength
1 kg/kg
pharm_class
Microsomal Triglyceride Transfer Protein Inhibitors [MoA]
marketing_start_date
20160322
spl_id
006c5442-a860-4e2e-9017-49369cfd5097
active_ingredient_name
LOMITAPIDE MESYLATE
package_ndc
10122-410-28
package_description
28 CAPSULE in 1 BOTTLE (10122-410-28)
package_marketing_start_date
22-MAR-16
manufacturer_name
Amryt Pharmaceuticals DAC
unii
X4S83CP54E
spl_set_id
e4c45bb5-15f4-437e-ab98-a649b3676d14
upc
0310122420281
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_13809
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect33471
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_72302
owl#annotatedSource
t280271
owl#someValuesFrom
t2911828