teduglutide
CHEBI:CHEBI_72305
Definition
A 33-membered polypeptide consisting of His, Gly, Asp, Gly, Ser, Phe, Ser, Asp, Glu, Met, Asn, Thr, Ile, Leu, Asp, Asn, Leu, Ala, Ala, Arg, Asp, Phe, Ile, Asn, Trp, Leu, Ile, Gln, Thr, Lys, Ile, Thr and Asp residues joined in sequence. A glucagon-like peptide-2 receptor agonist used for the treatment of short-bowel syndrome.
Chemical Information
- Molecular Formula
- C164H252N44O55S
- Molecular Mass
- 3752.08200
- Charge
- 0
- SMILES
- CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O
- InChI
- InChI=1S/C164H252N44O55S/c1-21-77(11)126(156(255)187-95(44-46-114(167)214)141(240)206-130(83(17)211)160(259)186-93(42-33-34-49-165)140(239)202-129(80(14)24-4)159(258)208-131(84(18)212)161(260)200-111(163(262)263)66-125(230)231)203-151(250)100(54-76(9)10)189-145(244)103(57-88-67-175-92-41-32-31-40-90(88)92)192-147(246)105(60-116(169)216)199-157(256)127(78(12)22-2)204-152(251)102(56-87-38-29-26-30-39-87)190-149(248)109(64-123(226)227)195-137(236)94(43-35-50-174-164(171)172)183-134(233)82(16)179-133(232)81(15)180-142(241)98(52-74(5)6)188-146(245)104(59-115(168)215)194-150(249)110(65-124(228)229)196-143(242)99(53-75(7)8)198-158(257)128(79(13)23-3)205-162(261)132(85(19)213)207-153(252)106(61-117(170)217)193-139(238)97(48-51-264-20)185-138(237)96(45-47-120(220)221)184-148(247)108(63-122(224)225)197-155(254)113(72-210)201-144(243)101(55-86-36-27-25-28-37-86)191-154(253)112(71-209)182-119(219)70-177-136(235)107(62-121(222)223)181-118(218)69-176-135(234)91(166)58-89-68-173-73-178-89/h25-32,36-41,67-68,73-85,91,93-113,126-132,175,209-213H,21-24,33-35,42-66,69-72,165-166H2,1-20H3,(H2,167,214)(H2,168,215)(H2,169,216)(H2,170,217)(H,173,178)(H,176,234)(H,177,235)(H,179,232)(H,180,241)(H,181,218)(H,182,219)(H,183,233)(H,184,247)(H,185,237)(H,186,259)(H,187,255)(H,188,245)(H,189,244)(H,190,248)(H,191,253)(H,192,246)(H,193,238)(H,194,249)(H,195,236)(H,196,242)(H,197,254)(H,198,257)(H,199,256)(H,200,260)(H,201,243)(H,202,239)(H,203,250)(H,204,251)(H,205,261)(H,206,240)(H,207,252)(H,208,258)(H,220,221)(H,222,223)(H,224,225)(H,226,227)(H,228,229)(H,230,231)(H,262,263)(H4,171,172,174)/t77-,78-,79-,80-,81-,82-,83+,84+,85+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,126-,127-,128-,129-,130-,131-,132-/m0/s1
- InChIKey
- CILIXQOJUNDIDU-ASQIGDHWSA-N
Alternative Names
- (Gly2)GLP-2
- ALX 0600
- ALX-0600
- Gattex
- Glucagon-like peptide II (2-glycine) (human)
- Gly(2)-GLP-2
- HGDGSFSDEMNTILDNLAARDFINWLIQTKITD
- His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp
- teduglutide
- L-histidylglycyl-L-alpha-aspartylglycyl-L-seryl-L-phenylalanyl-L-seryl-L-alpha-aspartyl-L-alpha-glutamyl-L-methionyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-alpha-aspartyl-L-asparaginyl-L-leucyl-L-alanyl-L-alanyl-L-arginyl-L-alpha-aspartyl-L-phenylalanyl-L-isoleucyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-isoleucyl-L-glutaminyl-L-threonyl-L-lysyl-L-isoleucyl-L-threonyl-L-aspartic acid
Drug Classification
-
polypeptideView Class →
CHEBI:15841
-
t279113
-
t279761
-
t279859
-
t280080
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- core#notation
- CHEBI:72305
- DRON_00010000
- 1364468
- oboInOwl#hasDbXref
- Wikipedia:Teduglutide
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- core#notation
- CHEBI:72305
- rxcui
- 1364477
- route
- SUBCUTANEOUS
- active_ingredient_strength
- 5 mg/.5mL
- pharm_class
- Glucagon-Like Peptide 2 [Chemical/Ingredient]
- pharm_class_cs
- Glucagon-Like Peptide 2 [Chemical/Ingredient]
- package_marketing_start_date
- 14-DEC-22
- active_ingredient_name
- TEDUGLUTIDE
- package_ndc
- 17337-0264-1
- package_description
- 1 BAG in 1 DRUM (17337-0264-1) / 1 BOTTLE, GLASS in 1 BAG / .2 kg in 1 BOTTLE, GLASS
- manufacturer_name
- Takeda Pharmaceuticals America, Inc.
- nui
- N0000175140
- unii
- 7M19191IKG
- spl_set_id
- 66b69c1e-b25c-44d3-b5ff-1c1de9a516fa
- pharm_class_epc
- GLP-2 Analog [EPC]
- pharm_class_moa
- Glucagon-like Peptide-2 (GLP-2) Agonists [MoA]
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1364468
- oboInOwl#hasDbXref
- Wikipedia:Teduglutide
- oboInOwl#id
- CHEBI:72305
- brand_name
- Gattex
- brand_name_base
- Gattex
- generic_name
- Teduglutide
- dosage_form
- INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT
- listing_expiration_date
- 20241231
- marketing_start_date
- 20121221
- labeler_name
- DARMERICA, LLC
- product_ndc
- 17337-0264
- spl_id
- cf525633-8323-edb0-e053-2995a90a14c5
- application_number
- NDA203441
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_72311
- has_treatment
- http://purl.obolibrary.org/obo/DOID_0111454
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect33504
- owl#annotatedSource
- t280259
- owl#someValuesFrom
- t2910481