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PASIREOTIDE

CHEBI:CHEBI_72312

Definition

A six-membered homodetic cyclic peptide composed from L-phenylglycyl, D-tryptophyl, L-lysyl, O-benzyl-L-tyrosyl, L-phenylalanyl and modified L-hydroxyproline residues joined in sequence. A somatostatin analogue with pharmacologic properties mimicking those of the natural hormone somatostatin; used (as its diaspartate salt) for treatment of Cushing's disease.

Chemical Information

Molecular Formula
C58H66N10O9
Molecular Mass
1047.20620
Charge
0
SMILES
NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O)OC(=O)NCCN)c1ccccc1
InChI
InChI=1S/C58H66N10O9/c59-27-13-12-22-46-52(69)64-47(30-38-23-25-42(26-24-38)76-36-39-16-6-2-7-17-39)53(70)66-49(31-37-14-4-1-5-15-37)57(74)68-35-43(77-58(75)61-29-28-60)33-50(68)55(72)67-51(40-18-8-3-9-19-40)56(73)65-48(54(71)63-46)32-41-34-62-45-21-11-10-20-44(41)45/h1-11,14-21,23-26,34,43,46-51,62H,12-13,22,27-33,35-36,59-60H2,(H,61,75)(H,63,71)(H,64,69)(H,65,73)(H,66,70)(H,67,72)/t43-,46+,47+,48-,49+,50+,51+/m1/s1
InChIKey
VMZMNAABQBOLAK-DBILLSOUSA-N

Alternative Names

  • cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L- phenylalanyl-)
  • cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-benzyl-L-tyrosyl-L-phenylalanyl-(4R)-4-{[(2-aminoethyl)carbamoyl]oxy}-L-prolyl]
  • pasireotida
  • pasireotide
  • pasireotidum
  • SOM 230
  • SOM-230
  • SOM230

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Pasireotide
DRON_00010000
1364105
core#notation
CHEBI:72312

Additional References

Wikipedia:Pasireotide

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Pasireotide
DRON_00010000
1364105
oboInOwl#id
CHEBI:72312
generic_name
pasireotide
dosage_form
INJECTION, POWDER, FOR SUSPENSION
product_type
DRUG FOR FURTHER PROCESSING
marketing_category
DRUG FOR FURTHER PROCESSING
listing_expiration_date
20241231
route
SUBCUTANEOUS
marketing_start_date
20180712
labeler_name
Recordati Rare Diseases, Inc.
product_ndc
55292-142
spl_id
4271824f-51d2-4b75-ad55-389713a3f4e0
package_ndc
55292-142-01
package_description
1 KIT in 1 KIT (55292-142-01) * 6 mL in 1 VIAL, SINGLE-USE (55292-137-01) * 2 mL in 1 SYRINGE
brand_name
Signifor
brand_name_base
Signifor
application_number
NDA200677
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35610
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_72315
core#notation
CHEBI:72312
active_ingredient_name
PASIREOTIDE
rxcui
2049736
active_ingredient_strength
15 mg/mL
package_marketing_start_date
12-JUL-18
pharm_class_epc
Somatostatin Analog [EPC]
pharm_class
Somatostatin Receptor Agonists [MoA]
pharm_class_moa
Somatostatin Receptor Agonists [MoA]
manufacturer_name
Recordati Rare Diseases, Inc.
spl_set_id
a09a25fc-a5a3-0c82-e053-2995a90a5d74
unii
98H1T17066
nui
N0000000194
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_4916
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_72315
owl#annotatedSource
t280278
owl#someValuesFrom
t2910630