Discuss This Drug

cabozantinib

CHEBI:CHEBI_72317

Definition

A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.

Chemical Information

Molecular Formula
C28H24FN3O5
Molecular Mass
501.50570
Charge
0
SMILES
COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
InChI
InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
InChIKey
ONIQOQHATWINJY-UHFFFAOYSA-N

Alternative Names

  • BMS 907351
  • BMS-907351
  • N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
  • XL 184
  • XL-184
  • XL184

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:72317
DRON_00010000
1363268
oboInOwl#hasDbXref
Wikipedia:Cabozantinib

Additional References

Wikipedia:Cabozantinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

rxcui
1364581
route
ORAL
listing_expiration_date
20251231
active_ingredient_strength
25 kg/25kg
package_marketing_start_date
02-SEP-24
pharm_class
Protein Kinase Inhibitors [MoA]
spl_id
285e1fb9-f372-7c43-e063-6394a90a728f
active_ingredient_name
CABOZANTINIB S-MALATE
package_ndc
42388-025-57
package_description
1 BOTTLE in 1 CARTON (42388-025-57) / 15 TABLET in 1 BOTTLE
manufacturer_name
Exelixis, Inc.
unii
DR7ST46X58
spl_set_id
1a0c3bea-c87b-4d25-bb44-5f0174da6b34
core#notation
CHEBI:72317
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1363268
generic_name
CABOZANTINIB (S)-MALATE
oboInOwl#hasDbXref
Wikipedia:Cabozantinib
oboInOwl#id
CHEBI:72317
dosage_form
CAPSULE
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
marketing_start_date
20121129
labeler_name
ESCIENTIA ADVANCED SCIENCES PRIVATE LIMITED
product_ndc
42388-025
brand_name
COMETRIQ
brand_name_base
COMETRIQ
application_number
NDA203756
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38637
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_0081416
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect33540
owl#annotatedSource
t280229
owl#someValuesFrom
t3000513